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• W2053644967 abstract "To determine whether the adenosine A2A receptor might play a role in L-DOPA-induced dyskinesia in Parkinson's disease, we analyzed changes in the expression of A2A receptor mRNA in response to intermittent treatment with L-DOPA in rats with dopaminergic denervation by 6-hydroxydopamine (OHDA) infusion into the medial forebrain bundle. Intermittent treatment with L-DOPA increased A2A receptor mRNA levels in the dopamine-depleted striatum of 6-OHDA-lesioned rats exhibiting behavioral sensitization to L-DOPA. These results suggest that A2A receptor activation is associated with the development of motor complications induced by L-DOPA treatment. Synapse 52:218–222, 2004. © 2004 Wiley-Liss, Inc." @default.
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• W2053644967 date "2004-01-01" @default.
• W2053644967 modified "2023-10-17" @default.
• W2053644967 title "Upregulation of striatal adenosine A2A receptor mRNA in 6-hydroxydopamine-lesioned rats intermittently treated with L-DOPA" @default.
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• W2053644967 doi "https://doi.org/10.1002/syn.20011" @default.
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• W2053644967 hasPublicationYear "2004" @default.
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