FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053646317> ?p ?o ?g. }

• W2053646317 endingPage "e1308" @default.
• W2053646317 startingPage "e1308" @default.
• W2053646317 abstract "Chronic psychological stress has been demonstrated to play an important role in several severe diseases, but whether it affects disease therapy or not remains unclear. Mesenchymal stem cells (MSCs) have been demonstrated to have therapeutic potentials in treating tissue injury based on their multidifferentiation potential toward various cell types. We investigated the effect of chronic restraint stress on therapeutic potential of MSCs on carbon tetrachloride (CCl4)-induced liver injury in mice. CCl4-induced mice were injected with enhanced green fluorescent protein–MSCs, which was followed by chronic restraint stress administration. Corticosterone and RU486, a glucocorticoid receptor (GR) antagonist, were employed in vivo and in vitro, too. In the present study, we illustrated that MSCs could repair liver injury by differentiating into myofibroblasts (MFs) which contribute to fibrosis, whereas stress repressed differentiation of MSCs into MFs displayed by reducing α-smooth muscle actin (α-SMA, a solid marker of MFs) expression. Whereas RU486 could maintain the liver injury reduction and liver fibrosis increases induced by MSCs in stressed mice and block the decrease of α-SMA expression induced by stress. Furthermore, chronic stress inhibited MFs differentiation from MSCs by inhibiting transforming growth factor-β1 (TGF-β1)/Smads signaling pathway which is essential for MFs differentiation. Chronic stress reduced autocrine TGF-β1 of MSCs, but not blunted activation of Smads. All these data suggested that corticosterone triggered by chronic stress impaired liver injury repair by MSCs through inhibiting TGF-β1 expression which results in reduced MFs differentiation of MSCs." @default.
• W2053646317 created "2016-06-24" @default.
• W2053646317 creator A5010578726 @default.
• W2053646317 creator A5033954124 @default.
• W2053646317 creator A5034704065 @default.
• W2053646317 creator A5044441524 @default.
• W2053646317 creator A5056329233 @default.
• W2053646317 creator A5059526453 @default.
• W2053646317 creator A5062243051 @default.
• W2053646317 creator A5062682623 @default.
• W2053646317 creator A5069831074 @default.
• W2053646317 creator A5081693703 @default.
• W2053646317 date "2014-06-26" @default.
• W2053646317 modified "2023-10-18" @default.
• W2053646317 title "Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF- β 1 generation" @default.
• W2053646317 cites W1487373628 @default.
• W2053646317 cites W1505584712 @default.
• W2053646317 cites W1520207918 @default.
• W2053646317 cites W1588127651 @default.
• W2053646317 cites W1960272757 @default.
• W2053646317 cites W1963643013 @default.
• W2053646317 cites W1963780536 @default.
• W2053646317 cites W1963922255 @default.
• W2053646317 cites W1970368333 @default.
• W2053646317 cites W1972305315 @default.
• W2053646317 cites W1976809932 @default.
• W2053646317 cites W1981269419 @default.
• W2053646317 cites W1996623301 @default.
• W2053646317 cites W2001247235 @default.
• W2053646317 cites W2003070777 @default.
• W2053646317 cites W2008104067 @default.
• W2053646317 cites W2008714016 @default.
• W2053646317 cites W2011904572 @default.
• W2053646317 cites W2013537969 @default.
• W2053646317 cites W2014216753 @default.
• W2053646317 cites W2016178284 @default.
• W2053646317 cites W2016193552 @default.
• W2053646317 cites W2020457566 @default.
• W2053646317 cites W2022194525 @default.
• W2053646317 cites W2023644363 @default.
• W2053646317 cites W2026756516 @default.
• W2053646317 cites W2040804852 @default.
• W2053646317 cites W2045681339 @default.
• W2053646317 cites W2047598541 @default.
• W2053646317 cites W2052377998 @default.
• W2053646317 cites W2068756999 @default.
• W2053646317 cites W2076940791 @default.
• W2053646317 cites W2083412018 @default.
• W2053646317 cites W2083796842 @default.
• W2053646317 cites W2086585598 @default.
• W2053646317 cites W2087422295 @default.
• W2053646317 cites W2089303016 @default.
• W2053646317 cites W2089848941 @default.
• W2053646317 cites W2090840455 @default.
• W2053646317 cites W2090875242 @default.
• W2053646317 cites W2096122790 @default.
• W2053646317 cites W2099071997 @default.
• W2053646317 cites W2106242725 @default.
• W2053646317 cites W2117033985 @default.
• W2053646317 cites W2120335459 @default.
• W2053646317 cites W2133578140 @default.
• W2053646317 cites W2142507661 @default.
• W2053646317 cites W2143600297 @default.
• W2053646317 cites W2146815044 @default.
• W2053646317 cites W2147512364 @default.
• W2053646317 cites W2159182678 @default.
• W2053646317 cites W2167630574 @default.
• W2053646317 cites W2168619375 @default.
• W2053646317 cites W2172257496 @default.
• W2053646317 cites W2327530675 @default.
• W2053646317 doi "https://doi.org/10.1038/cddis.2014.257" @default.
• W2053646317 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4611730" @default.
• W2053646317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24967970" @default.
• W2053646317 hasPublicationYear "2014" @default.
• W2053646317 type Work @default.
• W2053646317 sameAs 2053646317 @default.
• W2053646317 citedByCount "19" @default.
• W2053646317 countsByYear W20536463172016 @default.
• W2053646317 countsByYear W20536463172017 @default.
• W2053646317 countsByYear W20536463172018 @default.
• W2053646317 countsByYear W20536463172019 @default.
• W2053646317 countsByYear W20536463172020 @default.
• W2053646317 countsByYear W20536463172021 @default.
• W2053646317 countsByYear W20536463172022 @default.
• W2053646317 countsByYear W20536463172023 @default.
• W2053646317 crossrefType "journal-article" @default.
• W2053646317 hasAuthorship W2053646317A5010578726 @default.
• W2053646317 hasAuthorship W2053646317A5033954124 @default.
• W2053646317 hasAuthorship W2053646317A5034704065 @default.
• W2053646317 hasAuthorship W2053646317A5044441524 @default.
• W2053646317 hasAuthorship W2053646317A5056329233 @default.
• W2053646317 hasAuthorship W2053646317A5059526453 @default.
• W2053646317 hasAuthorship W2053646317A5062243051 @default.
• W2053646317 hasAuthorship W2053646317A5062682623 @default.
• W2053646317 hasAuthorship W2053646317A5069831074 @default.
• W2053646317 hasAuthorship W2053646317A5081693703 @default.
• W2053646317 hasBestOaLocation W20536463171 @default.
• W2053646317 hasConcept C134018914 @default.

• next