FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053646350> ?p ?o ?g. }

• W2053646350 endingPage "4091" @default.
• W2053646350 startingPage "4080" @default.
• W2053646350 abstract "Abstract Purpose: An increasing set of B-cell non-Hodgkin lymphomas (B-NHL) show a biased usage of IGKV3-20 and IGKV3-15 immunoglobulin genes, a feature that could be exploited for the development of ready-to-use, broadly applicable cancer vaccines. Experimental Design: The immunogenic properties of clonal IGKV3-20 and IGKV3-15 proteins were analyzed with particular focus on their ability to elicit cross-reactive responses against molecularly related IGKV proteins expressed by different B-cell lymphoproliferative disorders. Results: IGK+ lymphoma patients show humoral and T-cell responses to IGKV3-20 and IGKV3-15 proteins and IGKV3-specific cytotoxic T lymphocytes (CTL) can be easily induced ex vivo. IGKV3-20–specific CTLs cross-react against different IGKV3 proteins, an effect mediated by the presence of 21 shared, sometimes promiscuous, T-cell epitopes, presented by common HLA class I allele products, thus assuring a broad HLA coverage of IGKV3-based vaccines. Many natural epitope variants are carried by IGK light chains expressed by a broad spectrum of B-NHLs and we show that IGKV3-20–specific CTLs cross-react also against several of these variant epitopes. Both humoral and CTL-specific responses were induced by KLH-conjugated IGKV3-20 protein in HLA-A2-transgenic mice and coinjection of IGKV3-20–specific CTLs with IGKV3-20+ or IGKV3-15+ lymphoma cells into SCID mice totally prevented tumor growth, thus confirming the ability of these effectors to mediate efficient and cross-reactive cytotoxic responses also in vivo. Conclusions: These results provide the rationale to exploit IGKV3 proteins as “off-the-shelf” vaccines for a large fraction of lymphoma patients. Clin Cancer Res; 18(15); 4080–91. ©2012 AACR." @default.
• W2053646350 created "2016-06-24" @default.
• W2053646350 creator A5001956192 @default.
• W2053646350 creator A5008873156 @default.
• W2053646350 creator A5010135314 @default.
• W2053646350 creator A5013042239 @default.
• W2053646350 creator A5015626227 @default.
• W2053646350 creator A5016453181 @default.
• W2053646350 creator A5024760456 @default.
• W2053646350 creator A5025416035 @default.
• W2053646350 creator A5027726048 @default.
• W2053646350 creator A5033318238 @default.
• W2053646350 creator A5037367152 @default.
• W2053646350 creator A5045745778 @default.
• W2053646350 creator A5058093044 @default.
• W2053646350 creator A5061207143 @default.
• W2053646350 creator A5062688482 @default.
• W2053646350 creator A5064993921 @default.
• W2053646350 creator A5081879832 @default.
• W2053646350 date "2012-07-30" @default.
• W2053646350 modified "2023-09-25" @default.
• W2053646350 title "IGKV3 Proteins as Candidate “Off-the-Shelf” Vaccines for Kappa-Light Chain–Restricted B-Cell Non-Hodgkin Lymphomas" @default.
• W2053646350 cites W1500188050 @default.
• W2053646350 cites W1512178367 @default.
• W2053646350 cites W1516535702 @default.
• W2053646350 cites W1529651166 @default.
• W2053646350 cites W1548322053 @default.
• W2053646350 cites W1548460291 @default.
• W2053646350 cites W1971302107 @default.
• W2053646350 cites W1979825271 @default.
• W2053646350 cites W1983806918 @default.
• W2053646350 cites W1986273996 @default.
• W2053646350 cites W1986339942 @default.
• W2053646350 cites W1992699637 @default.
• W2053646350 cites W2010384595 @default.
• W2053646350 cites W2012873002 @default.
• W2053646350 cites W2019993505 @default.
• W2053646350 cites W2031514918 @default.
• W2053646350 cites W2041088998 @default.
• W2053646350 cites W2061650834 @default.
• W2053646350 cites W2068422269 @default.
• W2053646350 cites W2082673082 @default.
• W2053646350 cites W2083351284 @default.
• W2053646350 cites W2084132526 @default.
• W2053646350 cites W2086704878 @default.
• W2053646350 cites W2103406969 @default.
• W2053646350 cites W2109442096 @default.
• W2053646350 cites W2112346826 @default.
• W2053646350 cites W2124667997 @default.
• W2053646350 cites W2126292793 @default.
• W2053646350 cites W2127771003 @default.
• W2053646350 cites W2132832238 @default.
• W2053646350 cites W2135709828 @default.
• W2053646350 cites W2138205821 @default.
• W2053646350 cites W2140075371 @default.
• W2053646350 cites W2145113582 @default.
• W2053646350 cites W2146057844 @default.
• W2053646350 cites W2151155266 @default.
• W2053646350 cites W2151905249 @default.
• W2053646350 cites W2155127143 @default.
• W2053646350 cites W2160686798 @default.
• W2053646350 cites W2166579445 @default.
• W2053646350 cites W2313243731 @default.
• W2053646350 cites W310472318 @default.
• W2053646350 cites W42407565 @default.
• W2053646350 doi "https://doi.org/10.1158/1078-0432.ccr-12-0763" @default.
• W2053646350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22705988" @default.
• W2053646350 hasPublicationYear "2012" @default.
• W2053646350 type Work @default.
• W2053646350 sameAs 2053646350 @default.
• W2053646350 citedByCount "14" @default.
• W2053646350 countsByYear W20536463502013 @default.
• W2053646350 countsByYear W20536463502014 @default.
• W2053646350 countsByYear W20536463502015 @default.
• W2053646350 countsByYear W20536463502016 @default.
• W2053646350 countsByYear W20536463502017 @default.
• W2053646350 countsByYear W20536463502019 @default.
• W2053646350 countsByYear W20536463502020 @default.
• W2053646350 countsByYear W20536463502021 @default.
• W2053646350 countsByYear W20536463502022 @default.
• W2053646350 countsByYear W20536463502023 @default.
• W2053646350 crossrefType "journal-article" @default.
• W2053646350 hasAuthorship W2053646350A5001956192 @default.
• W2053646350 hasAuthorship W2053646350A5008873156 @default.
• W2053646350 hasAuthorship W2053646350A5010135314 @default.
• W2053646350 hasAuthorship W2053646350A5013042239 @default.
• W2053646350 hasAuthorship W2053646350A5015626227 @default.
• W2053646350 hasAuthorship W2053646350A5016453181 @default.
• W2053646350 hasAuthorship W2053646350A5024760456 @default.
• W2053646350 hasAuthorship W2053646350A5025416035 @default.
• W2053646350 hasAuthorship W2053646350A5027726048 @default.
• W2053646350 hasAuthorship W2053646350A5033318238 @default.
• W2053646350 hasAuthorship W2053646350A5037367152 @default.
• W2053646350 hasAuthorship W2053646350A5045745778 @default.
• W2053646350 hasAuthorship W2053646350A5058093044 @default.
• W2053646350 hasAuthorship W2053646350A5061207143 @default.
• W2053646350 hasAuthorship W2053646350A5062688482 @default.
• W2053646350 hasAuthorship W2053646350A5064993921 @default.

• next