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- W2053646585 abstract "In multiple sclerosis, endogenous oligodendrocyte precursor cells (OPCs) attempt to remyelinate areas of myelin damage. During disease progression, however, these attempts fail. It has been suggested that modulating the inflammatory environment of the lesion might provide a promising therapeutic approach to promote endogenous remyelination. Microglia are known to play a central role in neuroinflammatory processes. To investigate the microglia phenotype that supports remyelination, we performed genome-wide gene expression analysis of microglia from the corpus callosum during demyelination and remyelination in the mouse cuprizone model, in which remyelination spontaneously occurs after an episode of toxin-induced primary demyelination. We provide evidence for the existence of a microglia phenotype that supports remyelination already at the onset of demyelination and persists throughout the remyelination process. Our data show that microglia are involved in the phagocytosis of myelin debris and apoptotic cells during demyelination. Furthermore, they express a cytokine and chemokine repertoire enabling them to activate and recruit endogenous OPCs to the lesion site and deliver trophic support during remyelination. This study not only provides a detailed transcriptomic analysis of the remyelination-supportive microglia phenotype but also reinforces the notion that the primary function of microglia is the maintenance of tissue homeostasis and the support of regeneration already at the earliest stages in the development of demyelinating lesions. © 2011 Wiley Periodicals, Inc." @default.
- W2053646585 created "2016-06-24" @default.
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- W2053646585 date "2011-11-09" @default.
- W2053646585 modified "2023-10-16" @default.
- W2053646585 title "Identification of a microglia phenotype supportive of remyelination" @default.
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- W2053646585 cites W2003674452 @default.
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- W2053646585 cites W2030621201 @default.
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- W2053646585 cites W2039171674 @default.
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- W2053646585 cites W2060837976 @default.
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- W2053646585 cites W2136119693 @default.
- W2053646585 cites W2145938600 @default.
- W2053646585 cites W2146101449 @default.
- W2053646585 cites W2148353419 @default.
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- W2053646585 doi "https://doi.org/10.1002/glia.21266" @default.
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- W2053646585 hasPublicationYear "2011" @default.
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