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- W2053647544 abstract "Vascular surgery to a large extent depends on the use of drugs that influence blood coagulability. Heparin, introduced in the 1920s, is widely used by vascular surgeons during the perioperative period, but seems to have lost some of its popularity probably because its long term use is cumbersome. In the late 1970s and early 1980s the distal arterial tree has increasingly been the target of reconstructive surgery or reopening procedures. As a result it became necessary to maintain patency over a long period of time by employing pharmacological measures. Old fashioned drugs, such as acetyl-salicylic acid (ASA) have attracted renewed interest in the last decade because of their potentially beneficial action as platelet stabilising agents. Indeed ASA is easy to prescribe and exact postoperative patient surveillance is not necessary, although the best dosage regimen i~ a matter of-continuing debate. The role of oral anticoagulants, such as coumadin and warfarin, has never been fully established and other drugs that influence either blood viscosity or red cell deformability ale currently undeF investigation. Prostacyclin analogues are interesting not only for their vasoactive potential but also because of their interaction with the intrinsic clotting system. Finally, fibrinolytic agents have attracted considerable interest for the treatment of both arterial and venous throm" @default.
- W2053647544 created "2016-06-24" @default.
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- W2053647544 date "1990-12-01" @default.
- W2053647544 modified "2023-09-24" @default.
- W2053647544 title "What is the role of oral anticoagulants and platelet inhibitors in peripheral vascular surgery?" @default.
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- W2053647544 doi "https://doi.org/10.1016/s0950-821x(05)80806-0" @default.
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