FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053660679> ?p ?o ?g. }

• W2053660679 endingPage "461" @default.
• W2053660679 startingPage "456" @default.
• W2053660679 abstract "Connexin 43 (Cx43) is a major gap junction (GJ) protein found in many mammalian cell types. The C-terminal (CT) domain of Cx43 has unique characteristics in terms of amino acid (aa) sequence and its length differs from other connexins. This CT domain can be associated with protein partners to regulate GJ assembly and degradation, which results in the direct control of gap junction intercellular communication (GJIC). However, the essential roles of the CT regions involved in these mechanisms have not been fully elucidated. In this study, we aimed to investigate the specific regions of Cx43CT involved in GJ formation and internalization. Wild type Cx43(382aa) and 10 CT truncated mutants were stably expressed in HeLa cells as GFP or DsRed tagged proteins. First, we found that the deletion of 235–382aa from Cx43 resulted in failure to make GJ and establish GJIC. Second, the Cx43 with 242–382aa CT deletion could form functional GJs and be internalized as annular gap junctions (AGJs). However, the plaques consisting of Cx43 with CT deletions (Δ242–382aa to Δ271–382aa) were longer than the plaques consisting of Cx43 with CT deletions (Δ302–382aa). Third, co-culture experiments of cells expressing wild type Cx43(382) with cells expressing Cx43CT mutants revealed that the directions of GJ internalization were dependent on the length of the respective CT. Moreover, a specific region, 325–342aa residues of Cx43, played an important role in the direction of GJ internalization. These results showed the important roles of the Cx43 C-terminus in GJ expression and its turnover." @default.
• W2053660679 created "2016-06-24" @default.
• W2053660679 creator A5021359937 @default.
• W2053660679 creator A5023038367 @default.
• W2053660679 creator A5026189087 @default.
• W2053660679 creator A5075913718 @default.
• W2053660679 date "2012-04-01" @default.
• W2053660679 modified "2023-10-07" @default.
• W2053660679 title "The role of the Cx43 C-terminus in GJ plaque formation and internalization" @default.
• W2053660679 cites W1607993735 @default.
• W2053660679 cites W1950518418 @default.
• W2053660679 cites W1968619333 @default.
• W2053660679 cites W1977845454 @default.
• W2053660679 cites W1981500327 @default.
• W2053660679 cites W2013546443 @default.
• W2053660679 cites W2017907028 @default.
• W2053660679 cites W2033084145 @default.
• W2053660679 cites W2035677700 @default.
• W2053660679 cites W2042526782 @default.
• W2053660679 cites W2055938328 @default.
• W2053660679 cites W2057334944 @default.
• W2053660679 cites W2057901283 @default.
• W2053660679 cites W2064382301 @default.
• W2053660679 cites W2074419686 @default.
• W2053660679 cites W2083786873 @default.
• W2053660679 cites W2085147804 @default.
• W2053660679 cites W2092848690 @default.
• W2053660679 cites W2113596951 @default.
• W2053660679 cites W2127153289 @default.
• W2053660679 cites W2138885980 @default.
• W2053660679 cites W2140769225 @default.
• W2053660679 cites W2142067945 @default.
• W2053660679 cites W2152551864 @default.
• W2053660679 cites W2166809896 @default.
• W2053660679 cites W2170550665 @default.
• W2053660679 doi "https://doi.org/10.1016/j.bbrc.2012.03.018" @default.
• W2053660679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22430144" @default.
• W2053660679 hasPublicationYear "2012" @default.
• W2053660679 type Work @default.
• W2053660679 sameAs 2053660679 @default.
• W2053660679 citedByCount "22" @default.
• W2053660679 countsByYear W20536606792012 @default.
• W2053660679 countsByYear W20536606792013 @default.
• W2053660679 countsByYear W20536606792014 @default.
• W2053660679 countsByYear W20536606792015 @default.
• W2053660679 countsByYear W20536606792016 @default.
• W2053660679 countsByYear W20536606792017 @default.
• W2053660679 countsByYear W20536606792018 @default.
• W2053660679 countsByYear W20536606792019 @default.
• W2053660679 countsByYear W20536606792020 @default.
• W2053660679 countsByYear W20536606792021 @default.
• W2053660679 countsByYear W20536606792023 @default.
• W2053660679 crossrefType "journal-article" @default.
• W2053660679 hasAuthorship W2053660679A5021359937 @default.
• W2053660679 hasAuthorship W2053660679A5023038367 @default.
• W2053660679 hasAuthorship W2053660679A5026189087 @default.
• W2053660679 hasAuthorship W2053660679A5075913718 @default.
• W2053660679 hasConcept C104317684 @default.
• W2053660679 hasConcept C139770010 @default.
• W2053660679 hasConcept C142613039 @default.
• W2053660679 hasConcept C143065580 @default.
• W2053660679 hasConcept C1491633281 @default.
• W2053660679 hasConcept C158157758 @default.
• W2053660679 hasConcept C174510640 @default.
• W2053660679 hasConcept C2780228694 @default.
• W2053660679 hasConcept C515207424 @default.
• W2053660679 hasConcept C54009773 @default.
• W2053660679 hasConcept C54355233 @default.
• W2053660679 hasConcept C57711820 @default.
• W2053660679 hasConcept C79879829 @default.
• W2053660679 hasConcept C81885089 @default.
• W2053660679 hasConcept C86803240 @default.
• W2053660679 hasConcept C95444343 @default.
• W2053660679 hasConceptScore W2053660679C104317684 @default.
• W2053660679 hasConceptScore W2053660679C139770010 @default.
• W2053660679 hasConceptScore W2053660679C142613039 @default.
• W2053660679 hasConceptScore W2053660679C143065580 @default.
• W2053660679 hasConceptScore W2053660679C1491633281 @default.
• W2053660679 hasConceptScore W2053660679C158157758 @default.
• W2053660679 hasConceptScore W2053660679C174510640 @default.
• W2053660679 hasConceptScore W2053660679C2780228694 @default.
• W2053660679 hasConceptScore W2053660679C515207424 @default.
• W2053660679 hasConceptScore W2053660679C54009773 @default.
• W2053660679 hasConceptScore W2053660679C54355233 @default.
• W2053660679 hasConceptScore W2053660679C57711820 @default.
• W2053660679 hasConceptScore W2053660679C79879829 @default.
• W2053660679 hasConceptScore W2053660679C81885089 @default.
• W2053660679 hasConceptScore W2053660679C86803240 @default.
• W2053660679 hasConceptScore W2053660679C95444343 @default.
• W2053660679 hasIssue "2" @default.
• W2053660679 hasLocation W20536606791 @default.
• W2053660679 hasLocation W20536606792 @default.
• W2053660679 hasOpenAccess W2053660679 @default.
• W2053660679 hasPrimaryLocation W20536606791 @default.
• W2053660679 hasRelatedWork W1744239203 @default.
• W2053660679 hasRelatedWork W1989127634 @default.
• W2053660679 hasRelatedWork W1996470658 @default.
• W2053660679 hasRelatedWork W2040850663 @default.

• next