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• W2053668585 abstract "Human leucocyte antigen (HLA) B*27 is a susceptibility allele to ankylosing spondylitis (AS). However, major AS-associated subtypes of HLA-B*27 and other HLA-B alleles vary in different ethnic populations. Herein, we examined HLA-B alleles in a total of 360 AS patients and 350 controls of Chinese Han ancestry. The HLA-B genotyping was performed with sequence-based typing (SBT) method. Six HLA-B*27 subtypes B*27:04, B*27:05, B*27:07, B*27:08, B*27:10 and B*27:15 were observed in the cohorts. HLA-B*27:04:01 and -B*27:05:02 appeared significantly increased in AS patients, which indicated as two major susceptibility alleles to AS. Homozygous B*27 was observed only in AS patients. There are 30 HLA-B alleles identified in the studies. HLA-B*15, especially B*15:01:01:01, appeared as the major allele type in the Chinese controls. Some common HLA-B alleles such as HLA-B*15, B*13, B*46 and B*51 were significantly reduced in Chinese AS patients. In conclusion, the studies profiled the HLA-B alleles, and identified major susceptibility subtypes of B27 to AS in Han Chinese population." @default.
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• W2053668585 date "2013-08-19" @default.
• W2053668585 modified "2023-09-25" @default.
• W2053668585 title "Profiling of HLA-B Alleles for Association Studies with Ankylosing Spondylitis in the Chinese Population" @default.
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• W2053668585 doi "https://doi.org/10.2174/1874312920130628001" @default.
• W2053668585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3778539" @default.
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