Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053670265> ?p ?o ?g. }
- W2053670265 endingPage "44" @default.
- W2053670265 startingPage "32" @default.
- W2053670265 abstract "Endogenously produced hydrogen sulfide (H2S) may have multiple functions in the brain including potent anti-inflammatory effects. Activated microglia can secrete various pro-inflammatory cytokines and neurotoxic mediators, which may contribute to hypoxic injuries in the developing brain. The aim of this study is to investigate the potential role of H2S in altering hypoxia-induced neurotoxicity via its anti-inflammatory actions as examined in vitro and in vivo models. Using the BV-2 microglial cell line, we found that sodium hydrosulfide (NaHS), a H2S donor, significantly inhibited hypoxia-induced microglial activation and suppressed subsequent pro-inflammatory factor release. In addition, treating murine primary cortical neurons with conditioned medium (CM) from hypoxia-stimulated microglia induced neuronal apoptosis, an effect that was reversed by CM treated with NaHS. Further, NaHS inhibited phosphorylation of the p65 subunit of NF-κB, phosphorylation of ERK and p38 but not JNK MAPK in these hypoxia-induced microglia. When administered in vivo to neonatal mice subjected to hypoxia, NaHS was found to attenuate neuron death, an effect that was associated with suppressed microglial activation, pro-inflammatory cytokines and NO levels. Taken together, H2S exerts neuroprotection against hypoxia-induced neurotoxicity through its anti-inflammatory effect in microglia. This effect appears to be attributable to inhibition of iNOS, NF-κB, ERK and p38 MAPK signaling pathways. Our results suggest a potential therapeutic application of H2S releasing drugs in hypoxic brain damage treatment." @default.
- W2053670265 created "2016-06-24" @default.
- W2053670265 creator A5004957511 @default.
- W2053670265 creator A5006564463 @default.
- W2053670265 creator A5010571980 @default.
- W2053670265 creator A5010577284 @default.
- W2053670265 creator A5017252015 @default.
- W2053670265 creator A5035898198 @default.
- W2053670265 creator A5064825247 @default.
- W2053670265 creator A5065058975 @default.
- W2053670265 creator A5067223991 @default.
- W2053670265 creator A5081816628 @default.
- W2053670265 date "2014-06-01" @default.
- W2053670265 modified "2023-10-18" @default.
- W2053670265 title "Hydrogen sulfide attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation" @default.
- W2053670265 cites W1536340959 @default.
- W2053670265 cites W1538376958 @default.
- W2053670265 cites W1549679997 @default.
- W2053670265 cites W1789963253 @default.
- W2053670265 cites W1805879606 @default.
- W2053670265 cites W1936498642 @default.
- W2053670265 cites W1964184187 @default.
- W2053670265 cites W1964467441 @default.
- W2053670265 cites W1968547119 @default.
- W2053670265 cites W1969208871 @default.
- W2053670265 cites W1977895192 @default.
- W2053670265 cites W1979685458 @default.
- W2053670265 cites W1987179322 @default.
- W2053670265 cites W1990266236 @default.
- W2053670265 cites W1996849473 @default.
- W2053670265 cites W1999088334 @default.
- W2053670265 cites W2007387141 @default.
- W2053670265 cites W2011629228 @default.
- W2053670265 cites W2016901103 @default.
- W2053670265 cites W2021235898 @default.
- W2053670265 cites W2022116223 @default.
- W2053670265 cites W2030592815 @default.
- W2053670265 cites W2032893532 @default.
- W2053670265 cites W2037390262 @default.
- W2053670265 cites W2045798092 @default.
- W2053670265 cites W2048080288 @default.
- W2053670265 cites W2061251502 @default.
- W2053670265 cites W2073700467 @default.
- W2053670265 cites W2076786048 @default.
- W2053670265 cites W2078739145 @default.
- W2053670265 cites W2079714323 @default.
- W2053670265 cites W2086676999 @default.
- W2053670265 cites W2089212697 @default.
- W2053670265 cites W2094944142 @default.
- W2053670265 cites W2103131046 @default.
- W2053670265 cites W2118433899 @default.
- W2053670265 cites W2122797923 @default.
- W2053670265 cites W2126302474 @default.
- W2053670265 cites W2130623349 @default.
- W2053670265 cites W2133511841 @default.
- W2053670265 cites W2136334817 @default.
- W2053670265 cites W2141610173 @default.
- W2053670265 cites W2159265751 @default.
- W2053670265 doi "https://doi.org/10.1016/j.phrs.2014.04.009" @default.
- W2053670265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24788079" @default.
- W2053670265 hasPublicationYear "2014" @default.
- W2053670265 type Work @default.
- W2053670265 sameAs 2053670265 @default.
- W2053670265 citedByCount "46" @default.
- W2053670265 countsByYear W20536702652014 @default.
- W2053670265 countsByYear W20536702652015 @default.
- W2053670265 countsByYear W20536702652016 @default.
- W2053670265 countsByYear W20536702652017 @default.
- W2053670265 countsByYear W20536702652018 @default.
- W2053670265 countsByYear W20536702652019 @default.
- W2053670265 countsByYear W20536702652020 @default.
- W2053670265 countsByYear W20536702652021 @default.
- W2053670265 countsByYear W20536702652022 @default.
- W2053670265 countsByYear W20536702652023 @default.
- W2053670265 crossrefType "journal-article" @default.
- W2053670265 hasAuthorship W2053670265A5004957511 @default.
- W2053670265 hasAuthorship W2053670265A5006564463 @default.
- W2053670265 hasAuthorship W2053670265A5010571980 @default.
- W2053670265 hasAuthorship W2053670265A5010577284 @default.
- W2053670265 hasAuthorship W2053670265A5017252015 @default.
- W2053670265 hasAuthorship W2053670265A5035898198 @default.
- W2053670265 hasAuthorship W2053670265A5064825247 @default.
- W2053670265 hasAuthorship W2053670265A5065058975 @default.
- W2053670265 hasAuthorship W2053670265A5067223991 @default.
- W2053670265 hasAuthorship W2053670265A5081816628 @default.
- W2053670265 hasConcept C150903083 @default.
- W2053670265 hasConcept C178790620 @default.
- W2053670265 hasConcept C185592680 @default.
- W2053670265 hasConcept C203014093 @default.
- W2053670265 hasConcept C207001950 @default.
- W2053670265 hasConcept C25498285 @default.
- W2053670265 hasConcept C2776914184 @default.
- W2053670265 hasConcept C2779491297 @default.
- W2053670265 hasConcept C2779830541 @default.
- W2053670265 hasConcept C2780519940 @default.
- W2053670265 hasConcept C2780564542 @default.
- W2053670265 hasConcept C29730261 @default.
- W2053670265 hasConcept C51551487 @default.