Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053670354> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2053670354 abstract "Shh signaling is required for various cardiac developmental processes including the looping of heart tube and specification of cardiomyogenesis. Consistently, Shh mutant mice display the abnormalities in heart tube formation and specification of the myocardial and outflow tract. A multifunctional receptor Cdo functions as a Shh coreceptor to fully activate Shh signaling and Cdo deficient mice exhibit multiple defects in embryonic development, associated with the decreased Shh activity. However its role in heart development is entirely unknown. This study examined the role of Cdo in heart development and cardiomyogenesis using Cdo deficient (Cdo-/-) mice. Histological and morphological analyses revealed development of dilated cardiomyopathy (DCM) with a frequent death around 3 weeks of age. Echocardiographic analyses of Cdo-/- mice at 2 weeks confirmed the dilated phenotype of the heart with a significant decrease in the left ventricular fractional shortening. Patch clamp experiments revealed an increase in Ito and reduction in IK1, without any significant changes in action potential duration (APD) in Cdo-/- cariomyocytes. A major gap junctional protein Connexin 43 (Cx43) appears to be localized at the lateral border of the Cdo-/- cardiomyocytes whereas Cx43 remained predominately at the intercalated disk in wildtype cardiomyocytes. Furthermore the phosphorylation status of Cx43 was altered in Cdo-/- hearts. Taken together, these data suggest that Cdo signaling may influence the phosphorylation status and distribution of Cx43 thereby regulating intercellular communication and functionality of cardiomyocytes." @default.
- W2053670354 created "2016-06-24" @default.
- W2053670354 creator A5000561668 @default.
- W2053670354 creator A5004295906 @default.
- W2053670354 creator A5009247708 @default.
- W2053670354 creator A5055732430 @default.
- W2053670354 creator A5084900872 @default.
- W2053670354 date "2015-01-01" @default.
- W2053670354 modified "2023-09-29" @default.
- W2053670354 title "Cdo Deficient Mice Display Cardiomyopathy with Alterations in Connexins" @default.
- W2053670354 doi "https://doi.org/10.1016/j.bpj.2014.11.1495" @default.
- W2053670354 hasPublicationYear "2015" @default.
- W2053670354 type Work @default.
- W2053670354 sameAs 2053670354 @default.
- W2053670354 citedByCount "0" @default.
- W2053670354 crossrefType "journal-article" @default.
- W2053670354 hasAuthorship W2053670354A5000561668 @default.
- W2053670354 hasAuthorship W2053670354A5004295906 @default.
- W2053670354 hasAuthorship W2053670354A5009247708 @default.
- W2053670354 hasAuthorship W2053670354A5055732430 @default.
- W2053670354 hasAuthorship W2053670354A5084900872 @default.
- W2053670354 hasBestOaLocation W20536703541 @default.
- W2053670354 hasConcept C104317684 @default.
- W2053670354 hasConcept C11960822 @default.
- W2053670354 hasConcept C126322002 @default.
- W2053670354 hasConcept C127716648 @default.
- W2053670354 hasConcept C134018914 @default.
- W2053670354 hasConcept C145103041 @default.
- W2053670354 hasConcept C158157758 @default.
- W2053670354 hasConcept C164705383 @default.
- W2053670354 hasConcept C185592680 @default.
- W2053670354 hasConcept C2776383484 @default.
- W2053670354 hasConcept C2778198053 @default.
- W2053670354 hasConcept C2778797674 @default.
- W2053670354 hasConcept C2780228694 @default.
- W2053670354 hasConcept C2781175142 @default.
- W2053670354 hasConcept C55493867 @default.
- W2053670354 hasConcept C62425271 @default.
- W2053670354 hasConcept C71924100 @default.
- W2053670354 hasConcept C79879829 @default.
- W2053670354 hasConcept C86803240 @default.
- W2053670354 hasConcept C95444343 @default.
- W2053670354 hasConceptScore W2053670354C104317684 @default.
- W2053670354 hasConceptScore W2053670354C11960822 @default.
- W2053670354 hasConceptScore W2053670354C126322002 @default.
- W2053670354 hasConceptScore W2053670354C127716648 @default.
- W2053670354 hasConceptScore W2053670354C134018914 @default.
- W2053670354 hasConceptScore W2053670354C145103041 @default.
- W2053670354 hasConceptScore W2053670354C158157758 @default.
- W2053670354 hasConceptScore W2053670354C164705383 @default.
- W2053670354 hasConceptScore W2053670354C185592680 @default.
- W2053670354 hasConceptScore W2053670354C2776383484 @default.
- W2053670354 hasConceptScore W2053670354C2778198053 @default.
- W2053670354 hasConceptScore W2053670354C2778797674 @default.
- W2053670354 hasConceptScore W2053670354C2780228694 @default.
- W2053670354 hasConceptScore W2053670354C2781175142 @default.
- W2053670354 hasConceptScore W2053670354C55493867 @default.
- W2053670354 hasConceptScore W2053670354C62425271 @default.
- W2053670354 hasConceptScore W2053670354C71924100 @default.
- W2053670354 hasConceptScore W2053670354C79879829 @default.
- W2053670354 hasConceptScore W2053670354C86803240 @default.
- W2053670354 hasConceptScore W2053670354C95444343 @default.
- W2053670354 hasLocation W20536703541 @default.
- W2053670354 hasOpenAccess W2053670354 @default.
- W2053670354 hasPrimaryLocation W20536703541 @default.
- W2053670354 hasRelatedWork W1187757771 @default.
- W2053670354 hasRelatedWork W1801584833 @default.
- W2053670354 hasRelatedWork W1977052847 @default.
- W2053670354 hasRelatedWork W1997426465 @default.
- W2053670354 hasRelatedWork W2018132252 @default.
- W2053670354 hasRelatedWork W2052146653 @default.
- W2053670354 hasRelatedWork W2085291856 @default.
- W2053670354 hasRelatedWork W2147917329 @default.
- W2053670354 hasRelatedWork W2152220038 @default.
- W2053670354 hasRelatedWork W2157779708 @default.
- W2053670354 hasRelatedWork W2168537427 @default.
- W2053670354 hasRelatedWork W2282333059 @default.
- W2053670354 hasRelatedWork W2319329745 @default.
- W2053670354 hasRelatedWork W2342475143 @default.
- W2053670354 hasRelatedWork W2412488771 @default.
- W2053670354 hasRelatedWork W2901135430 @default.
- W2053670354 hasRelatedWork W2997605871 @default.
- W2053670354 hasRelatedWork W3009058866 @default.
- W2053670354 hasRelatedWork W3161865177 @default.
- W2053670354 hasRelatedWork W2182480309 @default.
- W2053670354 isParatext "false" @default.
- W2053670354 isRetracted "false" @default.
- W2053670354 magId "2053670354" @default.
- W2053670354 workType "article" @default.