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• W2053671363 abstract "Recognition of the -10 promoter consensus element by region 2 of the bacterial RNA polymerase sigma subunit is a key step in transcription initiation. sigma also functions as an elongation factor, inducing transcription pausing by interacting with transcribed DNA non-template strand sequences that are similar to the -10 element sequence. Here, we show that the region 1.2 of Escherichia coli sigma70, whose function was heretofore unknown, is strictly required for efficient recognition of the non-template strand of -10-like pause-inducing DNA sequence by sigma region 2, and for sigma-dependent promoter-proximal pausing. Recognition of the fork-junction promoter DNA by RNA polymerase holoenzyme also requires sigma region 1.2 and thus resembles the pause-inducing sequence recognition. Our results, together with available structural data, support a model where sigma region 1.2 acts as a core RNA polymerase-dependent allosteric switch that modulates non-template DNA strand recognition by sigma region 2 during transcription initiation and elongation." @default.
• W2053671363 created "2016-06-24" @default.
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• W2053671363 date "2007-02-01" @default.
• W2053671363 modified "2023-09-25" @default.
• W2053671363 title "Region 1.2 of the RNA polymerase σ subunit controls recognition of the −10 promoter element" @default.
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• W2053671363 doi "https://doi.org/10.1038/sj.emboj.7601555" @default.
• W2053671363 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1852845" @default.
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