Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053673553> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2053673553 endingPage "295" @default.
- W2053673553 startingPage "292" @default.
- W2053673553 abstract "In Egypt, β-thalassemia is the most common hereditary hemolytic anemia. Cardiac dysfunction, secondary to iron overload with formation of oxygen free radicals, is the most common cause of death in β-thalassemia patients. This study was designed to determine whether the allelic genotype of apolipoprotein E (Apo E), which exhibits antioxidant properties, could represent a genetic risk factor for the development of left ventricular (LV) dysfunction in β-thalassemia major. Fifty Egyptian β-thalassemia major patients were subjected to echocardiography to assess LV function. Apo E genotyping by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) was done for all patients in addition to 50 age and sex matched healthy control subjects. Patients were classified into three groups. Group I and II were clinically asymptomatic. Group II subjects had evidence of LV dilatation, while Group III patients had clinical and echocardiographic findings of LV failure. Apo E4 allele was significantly higher among Group II and III than in controls. In conclusion, Apo E4 allele can be considered as a genetic risk factor for LV dysfunctions in β-thalassemic patients. It could be used as predictive indicator for additional risk of LV failure, particularly in asymptomatic patients with LV dilatation, requiring a closer follow-up, to prevent further disease progression." @default.
- W2053673553 created "2016-06-24" @default.
- W2053673553 creator A5015903533 @default.
- W2053673553 creator A5025662872 @default.
- W2053673553 creator A5026650025 @default.
- W2053673553 creator A5054112040 @default.
- W2053673553 creator A5085868346 @default.
- W2053673553 date "2013-07-01" @default.
- W2053673553 modified "2023-09-26" @default.
- W2053673553 title "Apolipoprotein E gene polymorphism and the risk of left ventricular dysfunction among Egyptian β-thalassemia major" @default.
- W2053673553 cites W1524143065 @default.
- W2053673553 cites W1985859760 @default.
- W2053673553 cites W1989892480 @default.
- W2053673553 cites W2001592927 @default.
- W2053673553 cites W2035201811 @default.
- W2053673553 cites W2055490661 @default.
- W2053673553 cites W2063019852 @default.
- W2053673553 cites W2082283198 @default.
- W2053673553 cites W2101099004 @default.
- W2053673553 cites W2101929653 @default.
- W2053673553 cites W2111953437 @default.
- W2053673553 cites W2162846333 @default.
- W2053673553 cites W2168463967 @default.
- W2053673553 cites W324421524 @default.
- W2053673553 cites W4246480901 @default.
- W2053673553 doi "https://doi.org/10.1016/j.gene.2013.03.134" @default.
- W2053673553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23590983" @default.
- W2053673553 hasPublicationYear "2013" @default.
- W2053673553 type Work @default.
- W2053673553 sameAs 2053673553 @default.
- W2053673553 citedByCount "9" @default.
- W2053673553 countsByYear W20536735532014 @default.
- W2053673553 countsByYear W20536735532015 @default.
- W2053673553 countsByYear W20536735532017 @default.
- W2053673553 countsByYear W20536735532018 @default.
- W2053673553 countsByYear W20536735532019 @default.
- W2053673553 countsByYear W20536735532021 @default.
- W2053673553 countsByYear W20536735532022 @default.
- W2053673553 crossrefType "journal-article" @default.
- W2053673553 hasAuthorship W2053673553A5015903533 @default.
- W2053673553 hasAuthorship W2053673553A5025662872 @default.
- W2053673553 hasAuthorship W2053673553A5026650025 @default.
- W2053673553 hasAuthorship W2053673553A5054112040 @default.
- W2053673553 hasAuthorship W2053673553A5085868346 @default.
- W2053673553 hasConcept C104317684 @default.
- W2053673553 hasConcept C126322002 @default.
- W2053673553 hasConcept C135763542 @default.
- W2053673553 hasConcept C164705383 @default.
- W2053673553 hasConcept C168007829 @default.
- W2053673553 hasConcept C180754005 @default.
- W2053673553 hasConcept C2777799968 @default.
- W2053673553 hasConcept C2777910003 @default.
- W2053673553 hasConcept C2778163477 @default.
- W2053673553 hasConcept C31467283 @default.
- W2053673553 hasConcept C50440223 @default.
- W2053673553 hasConcept C54355233 @default.
- W2053673553 hasConcept C62746215 @default.
- W2053673553 hasConcept C71924100 @default.
- W2053673553 hasConcept C86803240 @default.
- W2053673553 hasConcept C90924648 @default.
- W2053673553 hasConceptScore W2053673553C104317684 @default.
- W2053673553 hasConceptScore W2053673553C126322002 @default.
- W2053673553 hasConceptScore W2053673553C135763542 @default.
- W2053673553 hasConceptScore W2053673553C164705383 @default.
- W2053673553 hasConceptScore W2053673553C168007829 @default.
- W2053673553 hasConceptScore W2053673553C180754005 @default.
- W2053673553 hasConceptScore W2053673553C2777799968 @default.
- W2053673553 hasConceptScore W2053673553C2777910003 @default.
- W2053673553 hasConceptScore W2053673553C2778163477 @default.
- W2053673553 hasConceptScore W2053673553C31467283 @default.
- W2053673553 hasConceptScore W2053673553C50440223 @default.
- W2053673553 hasConceptScore W2053673553C54355233 @default.
- W2053673553 hasConceptScore W2053673553C62746215 @default.
- W2053673553 hasConceptScore W2053673553C71924100 @default.
- W2053673553 hasConceptScore W2053673553C86803240 @default.
- W2053673553 hasConceptScore W2053673553C90924648 @default.
- W2053673553 hasIssue "2" @default.
- W2053673553 hasLocation W20536735531 @default.
- W2053673553 hasLocation W20536735532 @default.
- W2053673553 hasOpenAccess W2053673553 @default.
- W2053673553 hasPrimaryLocation W20536735531 @default.
- W2053673553 hasRelatedWork W1579334360 @default.
- W2053673553 hasRelatedWork W2039709676 @default.
- W2053673553 hasRelatedWork W2106455172 @default.
- W2053673553 hasRelatedWork W2158510364 @default.
- W2053673553 hasRelatedWork W2167463386 @default.
- W2053673553 hasRelatedWork W2182370226 @default.
- W2053673553 hasRelatedWork W2377518790 @default.
- W2053673553 hasRelatedWork W2394359576 @default.
- W2053673553 hasRelatedWork W2471536761 @default.
- W2053673553 hasRelatedWork W3031643465 @default.
- W2053673553 hasVolume "524" @default.
- W2053673553 isParatext "false" @default.
- W2053673553 isRetracted "false" @default.
- W2053673553 magId "2053673553" @default.
- W2053673553 workType "article" @default.