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• W2053673825 abstract "3alpha-Hydroxy-20-oxo-5alpha-pregnan-21-yl hemisuccinate (8) was produced by partial acylation of 3alpha,21-dihydroxy-5alpha-pregnan-20-one (14). 3alpha-Fluoro-5alpha-pregnan-20-one (9) was prepared by treatment of 3beta-hydroxy-5alpha-pregnan-20-one (11) with DAST and by solvolysis of tosylate 12 with tetrabutylammonium fluoride. A behavioral test on mice was performed using 3alpha-hydroxy-5alpha-pregnan-20-one (1) and compounds 8 and 9. Compound 8 was found to be inactive, while the fluoro derivative 9 selectively reduced aggressive behavior in mice more than the corresponding 3alpha-hydroxy compound 1; locomotion and other behavioral features were not affected." @default.
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• W2053673825 date "2001-01-01" @default.
• W2053673825 modified "2023-10-01" @default.
• W2053673825 title "Suppressing aggressive behavior with analogs of allopregnanolone (epalon)" @default.
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• W2053673825 doi "https://doi.org/10.1016/s0039-128x(00)00215-4" @default.
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