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• W2053673908 abstract "A new method for noncovalent immobilization of a peptide epitope on the virion surface was developed to simplify and standardize the procedures for producing viral nanocomplexes. The efficacy of this approach was demonstrated by the example of a model system comprising the tobacco mosaic virus, synthetic cationic polymer poly-N-ethyl-4-vinylpyridinium bromide, and a model polypeptide. The principle of sequential adsorption, underlying production of the triple system virion-polycation-protein, was used for electrostatic immobilization of a recombinant hydrophilic fragment of the influenza virus hemagglutinin (Flu1-3) on the virion surface. The method provided for a significant increase in the immunogenic activity of this potential artificial vaccine protein." @default.
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• W2053673908 date "2011-07-01" @default.
• W2053673908 modified "2023-09-27" @default.
• W2053673908 title "A new method for producing biologically active nanocomplexes by a noncovalent conjugation of proteins with viral particles" @default.
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• W2053673908 doi "https://doi.org/10.1134/s1068162011040169" @default.
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