Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053674384> ?p ?o ?g. }
- W2053674384 endingPage "65" @default.
- W2053674384 startingPage "58" @default.
- W2053674384 abstract "Background. Acute graft-versus-host disease (aGVHD) remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. It was hypothesized that type 1 cytokines promoted aGVHD and type 2 cytokines inhibited it. However, recent publications demonstrated contradictory results in murine models. Type 1/2 paradigm in aGVHD remains to be determined in human. Methods. Using enzyme-linked immunospot assay that reflects ongoing immune status in vivo, we measured spot-forming cells (SFCs) for interferon (IFN)-γ, interleukin (IL)-12, IL-4, and IL-10 in peripheral blood from 56 patients with hematological disorders who underwent allogeneic hematopoietic stem cell transplantation. Results. The numbers of IFN-γ and IL-4 SFCs in patients with grade II∼IV aGVHD were significantly higher than those in patients with grade 0∼I aGVHD. The enumeration of cytokine SFCs predicted aGVHD approximately 4 days before it became clinically evident, since IFN-γ SFCs in asymptomatic phase that later progressed into grade II∼IV aGVHD were elevated in 8 out of 8 evaluable patients. Similarly, IL-4 SFCs were elevated in 6 of 8 patients. In addition, Type 1 cytokine SFCs contributed to the intestinal, but not skin and hepatic aGVHD. Conclusions. Enzyme-linked immunospot assay is clinically useful for predicting aGVHD and detecting distinct end-organ targets following allogeneic hematopoietic stem cell transplantation." @default.
- W2053674384 created "2016-06-24" @default.
- W2053674384 creator A5002972080 @default.
- W2053674384 creator A5003151415 @default.
- W2053674384 creator A5022921244 @default.
- W2053674384 creator A5023968507 @default.
- W2053674384 creator A5029993402 @default.
- W2053674384 creator A5043502213 @default.
- W2053674384 creator A5053550345 @default.
- W2053674384 creator A5060221947 @default.
- W2053674384 creator A5069190762 @default.
- W2053674384 creator A5073856224 @default.
- W2053674384 creator A5078462673 @default.
- W2053674384 creator A5088882696 @default.
- W2053674384 date "2005-07-15" @default.
- W2053674384 modified "2023-10-17" @default.
- W2053674384 title "Prediction of Acute Graft-Versus-Host Disease and Detection of Distinct End-Organ Targets by Enumeration of Peripheral Blood Cytokine Spot-Forming Cells" @default.
- W2053674384 cites W1491641145 @default.
- W2053674384 cites W1518271910 @default.
- W2053674384 cites W1543788252 @default.
- W2053674384 cites W1592480150 @default.
- W2053674384 cites W1964616348 @default.
- W2053674384 cites W1966191534 @default.
- W2053674384 cites W1971753005 @default.
- W2053674384 cites W1973836102 @default.
- W2053674384 cites W1976161748 @default.
- W2053674384 cites W2006865619 @default.
- W2053674384 cites W2008514583 @default.
- W2053674384 cites W2010848542 @default.
- W2053674384 cites W2014993834 @default.
- W2053674384 cites W2017412050 @default.
- W2053674384 cites W2020694207 @default.
- W2053674384 cites W2037642074 @default.
- W2053674384 cites W2048649334 @default.
- W2053674384 cites W2049830668 @default.
- W2053674384 cites W2053278212 @default.
- W2053674384 cites W2055254092 @default.
- W2053674384 cites W2055808408 @default.
- W2053674384 cites W2059812639 @default.
- W2053674384 cites W2060643515 @default.
- W2053674384 cites W2068103783 @default.
- W2053674384 cites W2070431466 @default.
- W2053674384 cites W2072186294 @default.
- W2053674384 cites W2077718766 @default.
- W2053674384 cites W2080598623 @default.
- W2053674384 cites W2087090790 @default.
- W2053674384 cites W2090128233 @default.
- W2053674384 cites W2118577784 @default.
- W2053674384 cites W2135907511 @default.
- W2053674384 cites W2151630855 @default.
- W2053674384 cites W2155940448 @default.
- W2053674384 cites W2162805154 @default.
- W2053674384 cites W2186024901 @default.
- W2053674384 cites W2317780480 @default.
- W2053674384 cites W2322283967 @default.
- W2053674384 cites W2337085710 @default.
- W2053674384 cites W4249976898 @default.
- W2053674384 doi "https://doi.org/10.1097/01.tp.0000163431.57482.8c" @default.
- W2053674384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16003234" @default.
- W2053674384 hasPublicationYear "2005" @default.
- W2053674384 type Work @default.
- W2053674384 sameAs 2053674384 @default.
- W2053674384 citedByCount "14" @default.
- W2053674384 countsByYear W20536743842012 @default.
- W2053674384 countsByYear W20536743842013 @default.
- W2053674384 countsByYear W20536743842014 @default.
- W2053674384 countsByYear W20536743842015 @default.
- W2053674384 crossrefType "journal-article" @default.
- W2053674384 hasAuthorship W2053674384A5002972080 @default.
- W2053674384 hasAuthorship W2053674384A5003151415 @default.
- W2053674384 hasAuthorship W2053674384A5022921244 @default.
- W2053674384 hasAuthorship W2053674384A5023968507 @default.
- W2053674384 hasAuthorship W2053674384A5029993402 @default.
- W2053674384 hasAuthorship W2053674384A5043502213 @default.
- W2053674384 hasAuthorship W2053674384A5053550345 @default.
- W2053674384 hasAuthorship W2053674384A5060221947 @default.
- W2053674384 hasAuthorship W2053674384A5069190762 @default.
- W2053674384 hasAuthorship W2053674384A5073856224 @default.
- W2053674384 hasAuthorship W2053674384A5078462673 @default.
- W2053674384 hasAuthorship W2053674384A5088882696 @default.
- W2053674384 hasBestOaLocation W20536743841 @default.
- W2053674384 hasConcept C109159458 @default.
- W2053674384 hasConcept C126322002 @default.
- W2053674384 hasConcept C203014093 @default.
- W2053674384 hasConcept C2777408962 @default.
- W2053674384 hasConcept C2777910003 @default.
- W2053674384 hasConcept C2778690821 @default.
- W2053674384 hasConcept C2779134260 @default.
- W2053674384 hasConcept C2779972918 @default.
- W2053674384 hasConcept C28328180 @default.
- W2053674384 hasConcept C2911091166 @default.
- W2053674384 hasConcept C54355233 @default.
- W2053674384 hasConcept C71924100 @default.
- W2053674384 hasConcept C86803240 @default.
- W2053674384 hasConcept C8891405 @default.
- W2053674384 hasConceptScore W2053674384C109159458 @default.
- W2053674384 hasConceptScore W2053674384C126322002 @default.
- W2053674384 hasConceptScore W2053674384C203014093 @default.