Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053674553> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2053674553 abstract "Starvation arrests cultured mammalian cells in the G(1) restriction point of the cell cycle, whereas cancer cells generally lose the regulatory control of the cell cycle. Human lymphocytes, infected with Epstein-Barr virus (EBV), also lose their cell cycle control and produce immortal lymphoblastoid cell lines. We show that during starvation, EBV-lymphoblasts override the cell cycle arrest in the G(1) restriction point and continue cell division. Simultaneously, starvation activates apoptosis in an approximately half of the daughter cells in each cell generation. Continuos cell division and partial removal of cells by apoptosis results in stabilization of viable cell numbers, where a majority of viable cells are in the G(1) phase of the cell cycle. In contrast to starvation, anticancer drug etoposide activates apoptosis indiscriminately in all EBV-lymphoblasts and convertes all the viable cells into apoptotic. We conclude that the removal of surplus cells by apoptosis may represent a survival mechanism of transformed (i.e., cancer) cell population in nutrient restricted conditions, whereas nontransformed mammalian cells are arrested in the G(1) restriction point of the cell cycle." @default.
- W2053674553 created "2016-06-24" @default.
- W2053674553 creator A5030174427 @default.
- W2053674553 creator A5049886244 @default.
- W2053674553 creator A5077466041 @default.
- W2053674553 date "2004-04-02" @default.
- W2053674553 modified "2023-09-26" @default.
- W2053674553 title "Equilibrium Between Cell Division and Apoptosis in Immortal Cells as an Alternative to the G1 Restriction Mechanism in Mammalian Cells" @default.
- W2053674553 doi "https://doi.org/10.4161/cc.3.4.800" @default.
- W2053674553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15004536" @default.
- W2053674553 hasPublicationYear "2004" @default.
- W2053674553 type Work @default.
- W2053674553 sameAs 2053674553 @default.
- W2053674553 citedByCount "1" @default.
- W2053674553 countsByYear W20536745532014 @default.
- W2053674553 crossrefType "journal-article" @default.
- W2053674553 hasAuthorship W2053674553A5030174427 @default.
- W2053674553 hasAuthorship W2053674553A5049886244 @default.
- W2053674553 hasAuthorship W2053674553A5077466041 @default.
- W2053674553 hasBestOaLocation W20536745531 @default.
- W2053674553 hasConcept C105696609 @default.
- W2053674553 hasConcept C121608353 @default.
- W2053674553 hasConcept C124320809 @default.
- W2053674553 hasConcept C144024400 @default.
- W2053674553 hasConcept C1491633281 @default.
- W2053674553 hasConcept C149923435 @default.
- W2053674553 hasConcept C152857842 @default.
- W2053674553 hasConcept C190283241 @default.
- W2053674553 hasConcept C2908647359 @default.
- W2053674553 hasConcept C29537977 @default.
- W2053674553 hasConcept C31573885 @default.
- W2053674553 hasConcept C54355233 @default.
- W2053674553 hasConcept C81885089 @default.
- W2053674553 hasConcept C85813293 @default.
- W2053674553 hasConcept C86803240 @default.
- W2053674553 hasConcept C95444343 @default.
- W2053674553 hasConcept C96232424 @default.
- W2053674553 hasConceptScore W2053674553C105696609 @default.
- W2053674553 hasConceptScore W2053674553C121608353 @default.
- W2053674553 hasConceptScore W2053674553C124320809 @default.
- W2053674553 hasConceptScore W2053674553C144024400 @default.
- W2053674553 hasConceptScore W2053674553C1491633281 @default.
- W2053674553 hasConceptScore W2053674553C149923435 @default.
- W2053674553 hasConceptScore W2053674553C152857842 @default.
- W2053674553 hasConceptScore W2053674553C190283241 @default.
- W2053674553 hasConceptScore W2053674553C2908647359 @default.
- W2053674553 hasConceptScore W2053674553C29537977 @default.
- W2053674553 hasConceptScore W2053674553C31573885 @default.
- W2053674553 hasConceptScore W2053674553C54355233 @default.
- W2053674553 hasConceptScore W2053674553C81885089 @default.
- W2053674553 hasConceptScore W2053674553C85813293 @default.
- W2053674553 hasConceptScore W2053674553C86803240 @default.
- W2053674553 hasConceptScore W2053674553C95444343 @default.
- W2053674553 hasConceptScore W2053674553C96232424 @default.
- W2053674553 hasLocation W20536745531 @default.
- W2053674553 hasLocation W20536745532 @default.
- W2053674553 hasOpenAccess W2053674553 @default.
- W2053674553 hasPrimaryLocation W20536745531 @default.
- W2053674553 hasRelatedWork W1529063085 @default.
- W2053674553 hasRelatedWork W1536476593 @default.
- W2053674553 hasRelatedWork W161538641 @default.
- W2053674553 hasRelatedWork W1749865514 @default.
- W2053674553 hasRelatedWork W1980432311 @default.
- W2053674553 hasRelatedWork W1980503774 @default.
- W2053674553 hasRelatedWork W2029922809 @default.
- W2053674553 hasRelatedWork W2103642023 @default.
- W2053674553 hasRelatedWork W2114917071 @default.
- W2053674553 hasRelatedWork W2364906270 @default.
- W2053674553 hasRelatedWork W2397453387 @default.
- W2053674553 hasRelatedWork W2410842792 @default.
- W2053674553 hasRelatedWork W2566352496 @default.
- W2053674553 hasRelatedWork W2598228780 @default.
- W2053674553 hasRelatedWork W2808371678 @default.
- W2053674553 hasRelatedWork W3021059013 @default.
- W2053674553 hasRelatedWork W4785343 @default.
- W2053674553 hasRelatedWork W9409612 @default.
- W2053674553 hasRelatedWork W1881660462 @default.
- W2053674553 hasRelatedWork W3153391969 @default.
- W2053674553 isParatext "false" @default.
- W2053674553 isRetracted "false" @default.
- W2053674553 magId "2053674553" @default.
- W2053674553 workType "article" @default.