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• W2053676247 abstract "Delta/Notch signaling controls a wide spectrum of developmental processes, including body and leg segmentation in arthropods. The various functions of Delta/Notch signaling vary among species. For instance, in Cupiennius spiders, Delta/Notch signaling is essential for body and leg segmentation, whereas in Drosophila fruit flies it is involved in leg segmentation but not body segmentation. Therefore, to gain further insight into the functional evolution of Delta/Notch signaling in arthropod body and leg segmentation, we analyzed the function of the Delta (Gb′Delta) and Notch (Gb′Notch) genes in the hemimetabolous, intermediate-germ cricket Gryllus bimaculatus. We found that Gb′Delta and Gb′Notch were expressed in developing legs, and that RNAi silencing of Gb′Notch resulted in a marked reduction in leg length with a loss of joints. Our results suggest that the role of Notch signaling in leg segmentation is conserved in hemimetabolous insects. Furthermore, we found that Gb′Delta was expressed transiently in the posterior growth zone of the germband and in segmental stripes earlier than the appearance of wingless segmental stripes, whereas Gb′Notch was uniformly expressed in early germbands. RNAi knockdown of Gb′Delta or Gb′Notch expression resulted in malformation in body segments and a loss of posterior segments, the latter probably due to a defect in posterior growth. Therefore, in the cricket, Delta/Notch signaling might be required for proper morphogenesis of body segments and posterior elongation, but not for specification of segment boundaries." @default.
• W2053676247 created "2016-06-24" @default.
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• W2053676247 date "2011-09-01" @default.
• W2053676247 modified "2023-10-03" @default.
• W2053676247 title "Ancestral functions of Delta/Notch signaling in the formation of body and leg segments in the cricket<i>Gryllus bimaculatus</i>" @default.
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• W2053676247 doi "https://doi.org/10.1242/dev.060681" @default.
• W2053676247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21828099" @default.
• W2053676247 hasPublicationYear "2011" @default.
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