Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053676871> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2053676871 endingPage "1962" @default.
- W2053676871 startingPage "1959" @default.
- W2053676871 abstract "Two conflicting claims have been made about the effects that the selective serotonin-reuptake inhibitor (SSRI) antidepressants have on suicide risk: that increased SSRI use has reduced suicide rates, 1 Isacsson G Holmgren P Ahlner J Selective serotonin reuptake inhibitor antidepressants and the risk of suicide: a controlled forensic database study of 14,857 suicides. Acta Psychiatr Scand. 2005; 111: 286-290 Crossref PubMed Scopus (132) Google Scholar and that SSRIs increase suicide risk in some patients early in treatment. 2 Healy D Lines of evidence on the risks of suicide with selective serotonin reuptake inhibitors. Psychother Psychosom. 2003; 72: 71-79 Crossref PubMed Scopus (135) Google Scholar Without a gold-standard method for arbitrating these claims, we have to look for a convergence of imperfect evidence from a range of study types (table). TableStrengths and weaknesses of evidence on SSRIs and suicide Findings Strengths Limitations Meta-analyses Evidence of increased suicidal ideation and acts Aggregated number increases statistical power Short study periods Uncertainty about suicidal ideation as surrogate for suicide risk Randomised trials No evidence of increased risk Random assignment to SSRI or placebo Limited ability to detect effects because studies: Too small Too short Often exclude at-risk patients Observational studies Limited evidence of greater risk for SSRIs than TCAs Larger than randomised trials Confounding by indication Observe risks under routine practice Too few suicides Ecological studies Suggestive evidence that suicide rates have declined as SSRI prescriptions have increased Able to detect small effects aggregated over large exposed populations Limited capacity to test alternative explanations—eg, confounding Open table in a new tab Clinical trials in children, for childrenA new era for research in children is about to begin, and should be welcomed. On June 1, the EU Parliament announced draft amendments to the EU Medicines for Children legislation which pave the way for more clinical trials of paediatric prescribing. The goal is to provide age-specific evidence to improve the safety and efficacy of medications used for children. Full-Text PDF" @default.
- W2053676871 created "2016-06-24" @default.
- W2053676871 creator A5053840112 @default.
- W2053676871 date "2006-06-01" @default.
- W2053676871 modified "2023-09-23" @default.
- W2053676871 title "How have the SSRI antidepressants affected suicide risk?" @default.
- W2053676871 cites W1498649466 @default.
- W2053676871 cites W1971011777 @default.
- W2053676871 cites W1974552671 @default.
- W2053676871 cites W1979796529 @default.
- W2053676871 cites W1984249564 @default.
- W2053676871 cites W1998901719 @default.
- W2053676871 cites W2004840713 @default.
- W2053676871 cites W2012033425 @default.
- W2053676871 cites W2017340637 @default.
- W2053676871 cites W2017693744 @default.
- W2053676871 cites W2027923042 @default.
- W2053676871 cites W2051694141 @default.
- W2053676871 cites W2053684621 @default.
- W2053676871 cites W2063233085 @default.
- W2053676871 cites W2098927208 @default.
- W2053676871 cites W2099840408 @default.
- W2053676871 cites W2106164880 @default.
- W2053676871 cites W2114091773 @default.
- W2053676871 cites W2119015267 @default.
- W2053676871 cites W2124353882 @default.
- W2053676871 cites W2133302828 @default.
- W2053676871 cites W2133451385 @default.
- W2053676871 cites W2153778343 @default.
- W2053676871 cites W2162715159 @default.
- W2053676871 cites W2254051562 @default.
- W2053676871 cites W4236725792 @default.
- W2053676871 cites W4244588791 @default.
- W2053676871 doi "https://doi.org/10.1016/s0140-6736(06)68860-0" @default.
- W2053676871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16782468" @default.
- W2053676871 hasPublicationYear "2006" @default.
- W2053676871 type Work @default.
- W2053676871 sameAs 2053676871 @default.
- W2053676871 citedByCount "48" @default.
- W2053676871 countsByYear W20536768712012 @default.
- W2053676871 countsByYear W20536768712013 @default.
- W2053676871 countsByYear W20536768712014 @default.
- W2053676871 countsByYear W20536768712015 @default.
- W2053676871 countsByYear W20536768712016 @default.
- W2053676871 countsByYear W20536768712017 @default.
- W2053676871 countsByYear W20536768712020 @default.
- W2053676871 countsByYear W20536768712021 @default.
- W2053676871 countsByYear W20536768712022 @default.
- W2053676871 crossrefType "journal-article" @default.
- W2053676871 hasAuthorship W2053676871A5053840112 @default.
- W2053676871 hasConcept C118552586 @default.
- W2053676871 hasConcept C126322002 @default.
- W2053676871 hasConcept C15744967 @default.
- W2053676871 hasConcept C194828623 @default.
- W2053676871 hasConcept C2776641880 @default.
- W2053676871 hasConcept C2779177272 @default.
- W2053676871 hasConcept C2780092697 @default.
- W2053676871 hasConcept C3017944768 @default.
- W2053676871 hasConcept C526869908 @default.
- W2053676871 hasConcept C558461103 @default.
- W2053676871 hasConcept C71924100 @default.
- W2053676871 hasConcept C77350462 @default.
- W2053676871 hasConcept C95190672 @default.
- W2053676871 hasConceptScore W2053676871C118552586 @default.
- W2053676871 hasConceptScore W2053676871C126322002 @default.
- W2053676871 hasConceptScore W2053676871C15744967 @default.
- W2053676871 hasConceptScore W2053676871C194828623 @default.
- W2053676871 hasConceptScore W2053676871C2776641880 @default.
- W2053676871 hasConceptScore W2053676871C2779177272 @default.
- W2053676871 hasConceptScore W2053676871C2780092697 @default.
- W2053676871 hasConceptScore W2053676871C3017944768 @default.
- W2053676871 hasConceptScore W2053676871C526869908 @default.
- W2053676871 hasConceptScore W2053676871C558461103 @default.
- W2053676871 hasConceptScore W2053676871C71924100 @default.
- W2053676871 hasConceptScore W2053676871C77350462 @default.
- W2053676871 hasConceptScore W2053676871C95190672 @default.
- W2053676871 hasIssue "9527" @default.
- W2053676871 hasLocation W20536768711 @default.
- W2053676871 hasLocation W20536768712 @default.
- W2053676871 hasOpenAccess W2053676871 @default.
- W2053676871 hasPrimaryLocation W20536768711 @default.
- W2053676871 hasRelatedWork W118850467 @default.
- W2053676871 hasRelatedWork W1969229469 @default.
- W2053676871 hasRelatedWork W2053780207 @default.
- W2053676871 hasRelatedWork W2105730322 @default.
- W2053676871 hasRelatedWork W2108446531 @default.
- W2053676871 hasRelatedWork W2145768745 @default.
- W2053676871 hasRelatedWork W2160882381 @default.
- W2053676871 hasRelatedWork W2167188781 @default.
- W2053676871 hasRelatedWork W2570330491 @default.
- W2053676871 hasRelatedWork W2594582114 @default.
- W2053676871 hasVolume "367" @default.
- W2053676871 isParatext "false" @default.
- W2053676871 isRetracted "false" @default.
- W2053676871 magId "2053676871" @default.
- W2053676871 workType "article" @default.