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• W2053683231 startingPage "1671" @default.
• W2053683231 abstract "SPARC is an evolutionarily conserved collagen-binding extracellular matrix (ECM) glycoprotein whose morphogenetic contribution(s) to embryonic development remain elusive despite decades of research. We have therefore used Drosophila genetics to gain insight into the role of SPARC during embryogenesis. In Drosophila embryos, high levels of SPARC and other basal lamina components (such as network-forming collagen IV, laminin and perlecan) are synthesized and secreted by haemocytes, and assembled into basal laminae. A SPARC mutant was generated by P-element mutagenesis that is embryonic lethal because of multiple developmental defects. Whereas no differences in collagen IV immunostaining were observed in haemocytes between wild-type and SPARC-mutant embryos, collagen IV was not visible in basal laminae of SPARC-mutant embryos. In addition, the laminin network of SPARC-mutant embryos appeared fragmented and discontinuous by late embryogenesis. Transgenic expression of SPARC protein by haemocytes in SPARC-mutant embryos restored collagen IV and laminin continuity in basal laminae. However, transgenic expression of SPARC by neural cells failed to rescue collagen IV in basal laminae, indicating that the presence of collagen IV deposition requires SPARC expression by haemocytes. Our previous finding that haemocyte-derived SPARC protein levels are reduced in collagen-IV-mutant embryos and the observation that collagen-IV-mutant embryos showed a striking phenotypic similarity to SPARC-mutant embryos suggests a mutual dependence between these major basal laminae components during embryogenesis. Patterning defects and impaired condensation of the ventral nerve cord also resulted from the loss SPARC expression prior to haemocyte migration. Hence, SPARC is required for basal lamina maturation and condensation of the ventral nerve cord during Drosophila embryogenesis." @default.
• W2053683231 created "2016-06-24" @default.
• W2053683231 creator A5051855113 @default.
• W2053683231 creator A5054329605 @default.
• W2053683231 creator A5069365222 @default.
• W2053683231 creator A5077025894 @default.
• W2053683231 date "2008-05-15" @default.
• W2053683231 modified "2023-09-23" @default.
• W2053683231 title "Haemocyte-derived SPARC is required for collagen-IV-dependent stability of basal laminae in<i>Drosophila</i>embryos" @default.
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• W2053683231 doi "https://doi.org/10.1242/jcs.021931" @default.
• W2053683231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18445681" @default.
• W2053683231 hasPublicationYear "2008" @default.
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