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- W2053687744 abstract "The concepts of stem cells being resistant to therapy, stem-like cells existing in brain tumors, and these tumors initially responding to therapy followed by recurrence are well documented. On this foundation, a recent paper in Nature has demonstrated that CD133-expressing glioma cells in vivo and in culture are relatively resistant to radiation. The mechanism of resistance involves the cell-cycle-regulating proteins CHK1/CHK2. The data raise many questions about the details of radiobiology of stem-like cells in their native environment within tumors in vivo. These answers may lead to better optimization of radiation treatments and schedules for these patients." @default.
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- W2053687744 date "2006-12-01" @default.
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- W2053687744 title "Radiation resistance and stem-like cells in brain tumors" @default.
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- W2053687744 doi "https://doi.org/10.1016/j.ccr.2006.11.008" @default.
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