Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053693670> ?p ?o ?g. }
- W2053693670 endingPage "3341" @default.
- W2053693670 startingPage "3321" @default.
- W2053693670 abstract "Replacement of the methyl-thiazole moiety of GW501516 (a PPARdelta selective agonist) with [1,2,4]thiadiazole gave compound 21 which unexpectedly displayed submicromolar potency as a partial agonist at PPARalpha in addition to the high potency at PPARdelta. A structure-activity relationships study of 21 resulted in the identification of 40 as a potent and selective PPARalpha/delta dual agonist. Compound 40 and its close analogs represent a new series of PPARalpha/delta dual agonists. The high potency, high selectivity, significant gene induction, excellent PK profiles, low P450 inhibition or induction, and good in vivo efficacy in four animal models support 40 being selected as a pre-clinical study candidate, and may render 40 as a valuable pharmacological tool in elucidating the complex roles of PPARalpha/delta dual agonists, and the potential usage for the treatment of metabolic syndrome." @default.
- W2053693670 created "2016-06-24" @default.
- W2053693670 creator A5009483595 @default.
- W2053693670 creator A5012353323 @default.
- W2053693670 creator A5030740220 @default.
- W2053693670 creator A5036099832 @default.
- W2053693670 creator A5040869905 @default.
- W2053693670 creator A5042785839 @default.
- W2053693670 creator A5042837947 @default.
- W2053693670 creator A5043504008 @default.
- W2053693670 creator A5082255460 @default.
- W2053693670 creator A5086664284 @default.
- W2053693670 date "2008-03-15" @default.
- W2053693670 modified "2023-10-14" @default.
- W2053693670 title "Synthesis and structure–activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors α/δ dual agonists" @default.
- W2053693670 cites W1971572370 @default.
- W2053693670 cites W1974497317 @default.
- W2053693670 cites W1976023760 @default.
- W2053693670 cites W1976453844 @default.
- W2053693670 cites W1977666051 @default.
- W2053693670 cites W1983519362 @default.
- W2053693670 cites W1985588649 @default.
- W2053693670 cites W1991865316 @default.
- W2053693670 cites W1992898297 @default.
- W2053693670 cites W1993412402 @default.
- W2053693670 cites W2000151617 @default.
- W2053693670 cites W2009423060 @default.
- W2053693670 cites W2029190686 @default.
- W2053693670 cites W2047982128 @default.
- W2053693670 cites W2051381895 @default.
- W2053693670 cites W2055067929 @default.
- W2053693670 cites W2056281469 @default.
- W2053693670 cites W2059906195 @default.
- W2053693670 cites W2067108507 @default.
- W2053693670 cites W2088660229 @default.
- W2053693670 cites W2097205737 @default.
- W2053693670 cites W2120993382 @default.
- W2053693670 cites W2121853844 @default.
- W2053693670 cites W2140038597 @default.
- W2053693670 cites W2147421370 @default.
- W2053693670 cites W2166114438 @default.
- W2053693670 cites W2950002445 @default.
- W2053693670 doi "https://doi.org/10.1016/j.bmc.2007.12.005" @default.
- W2053693670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18155554" @default.
- W2053693670 hasPublicationYear "2008" @default.
- W2053693670 type Work @default.
- W2053693670 sameAs 2053693670 @default.
- W2053693670 citedByCount "25" @default.
- W2053693670 countsByYear W20536936702012 @default.
- W2053693670 countsByYear W20536936702013 @default.
- W2053693670 countsByYear W20536936702014 @default.
- W2053693670 countsByYear W20536936702020 @default.
- W2053693670 countsByYear W20536936702021 @default.
- W2053693670 countsByYear W20536936702022 @default.
- W2053693670 crossrefType "journal-article" @default.
- W2053693670 hasAuthorship W2053693670A5009483595 @default.
- W2053693670 hasAuthorship W2053693670A5012353323 @default.
- W2053693670 hasAuthorship W2053693670A5030740220 @default.
- W2053693670 hasAuthorship W2053693670A5036099832 @default.
- W2053693670 hasAuthorship W2053693670A5040869905 @default.
- W2053693670 hasAuthorship W2053693670A5042785839 @default.
- W2053693670 hasAuthorship W2053693670A5042837947 @default.
- W2053693670 hasAuthorship W2053693670A5043504008 @default.
- W2053693670 hasAuthorship W2053693670A5082255460 @default.
- W2053693670 hasAuthorship W2053693670A5086664284 @default.
- W2053693670 hasConcept C150903083 @default.
- W2053693670 hasConcept C170493617 @default.
- W2053693670 hasConcept C185592680 @default.
- W2053693670 hasConcept C187345961 @default.
- W2053693670 hasConcept C193042331 @default.
- W2053693670 hasConcept C202751555 @default.
- W2053693670 hasConcept C207001950 @default.
- W2053693670 hasConcept C2778938600 @default.
- W2053693670 hasConcept C38533456 @default.
- W2053693670 hasConcept C55493867 @default.
- W2053693670 hasConcept C57992300 @default.
- W2053693670 hasConcept C58732023 @default.
- W2053693670 hasConcept C7341990 @default.
- W2053693670 hasConcept C86803240 @default.
- W2053693670 hasConcept C98274493 @default.
- W2053693670 hasConceptScore W2053693670C150903083 @default.
- W2053693670 hasConceptScore W2053693670C170493617 @default.
- W2053693670 hasConceptScore W2053693670C185592680 @default.
- W2053693670 hasConceptScore W2053693670C187345961 @default.
- W2053693670 hasConceptScore W2053693670C193042331 @default.
- W2053693670 hasConceptScore W2053693670C202751555 @default.
- W2053693670 hasConceptScore W2053693670C207001950 @default.
- W2053693670 hasConceptScore W2053693670C2778938600 @default.
- W2053693670 hasConceptScore W2053693670C38533456 @default.
- W2053693670 hasConceptScore W2053693670C55493867 @default.
- W2053693670 hasConceptScore W2053693670C57992300 @default.
- W2053693670 hasConceptScore W2053693670C58732023 @default.
- W2053693670 hasConceptScore W2053693670C7341990 @default.
- W2053693670 hasConceptScore W2053693670C86803240 @default.
- W2053693670 hasConceptScore W2053693670C98274493 @default.
- W2053693670 hasIssue "6" @default.
- W2053693670 hasLocation W20536936701 @default.
- W2053693670 hasLocation W20536936702 @default.