FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053705516> ?p ?o ?g. }

• W2053705516 endingPage "369" @default.
• W2053705516 startingPage "363" @default.
• W2053705516 abstract "Objective To study the effects of ingestion of two different doses of supplemental kelp on the thyroid function of healthy euthyroid subjects. Methods We conducted a double-blind prospective clinical trial involving 36 healthy euthyroid subjects, who were randomly assigned to receive placebo (4 alfalfa capsules per day), low-dose kelp (2 kelp capsules and 2 alfalfa capsules per day), or high-dose kelp (4 kelp capsules per day) for 4 weeks. Thyrotropin (thyroid-stimulating hormone or TSH), free thyroxine, and total triiodothyronine were assessed at weeks 0, 4, and 6. Response to thyrotropin- releasing hormone stimulation, urinary iodine excretion, and basal metabolic rate were determined at weeks 0 and 4. Results TSH concentrations did not differ significantly between week 0 and week 4 in the placebo group (P = 0.16) but increased significantly in both the low-dose kelp (P = 0.04) and high-dose kelp (P = 0.002) groups. Free thyroxine concentrations decreased slightly but significantly after 4 weeks of placebo but were unchanged in the low-dose and the high-dose kelp groups. In contrast, total triiodothyronine levels did not differ significantly after 4 weeks of placebo or low-dose kelp therapy but were significantly decreased after high-dose kelp therapy (P = 0.04). Similarly, the thyrotropin-releasing hormone stimulation test showed no significant change in poststimulation TSH after 4 weeks in the placebo or low-dose kelp groups but revealed a significantly increased response after high-dose kelp therapy (P = 0.0002). The 24-hour urinary iodine excretion showed dose-dependent increases in the two kelp study groups. Basal metabolic rate did not change significantly in any study group during the 4-week study period. All thyroid laboratory values returned to baseline 2 weeks after cessation of kelp supplementation, except for TSH in the high-dose kelp group, which was significantly decreased. Conclusion Short-term dietary supplementation with kelp significantly increases both basal and poststimulation TSH. These findings corroborate previous studies on the effects of supplemental iodide given to euthyroid subjects for a similar period. Further studies are needed to determine whether long-term kelp supplementation would cause clinically significant thyroid disease. (Endocr Pract. 2003;9:363-369)" @default.
• W2053705516 created "2016-06-24" @default.
• W2053705516 creator A5016028400 @default.
• W2053705516 creator A5034432282 @default.
• W2053705516 creator A5041694329 @default.
• W2053705516 date "2003-10-01" @default.
• W2053705516 modified "2023-10-17" @default.
• W2053705516 title "Effects of Kelp Supplementation on Thyroid Function in Euthyroid Subjects" @default.
• W2053705516 cites W156300550 @default.
• W2053705516 cites W1965728060 @default.
• W2053705516 cites W1968881371 @default.
• W2053705516 cites W1989506878 @default.
• W2053705516 cites W1991514639 @default.
• W2053705516 cites W2000212705 @default.
• W2053705516 cites W2007447846 @default.
• W2053705516 cites W2027736044 @default.
• W2053705516 cites W2033405875 @default.
• W2053705516 cites W2060313926 @default.
• W2053705516 cites W2066260922 @default.
• W2053705516 cites W2068203152 @default.
• W2053705516 cites W2075480762 @default.
• W2053705516 cites W2075601201 @default.
• W2053705516 cites W2077166692 @default.
• W2053705516 cites W2089992526 @default.
• W2053705516 cites W2102609831 @default.
• W2053705516 cites W2123500254 @default.
• W2053705516 cites W2169004978 @default.
• W2053705516 cites W2222668813 @default.
• W2053705516 doi "https://doi.org/10.4158/ep.9.5.363" @default.
• W2053705516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14583417" @default.
• W2053705516 hasPublicationYear "2003" @default.
• W2053705516 type Work @default.
• W2053705516 sameAs 2053705516 @default.
• W2053705516 citedByCount "35" @default.
• W2053705516 countsByYear W20537055162012 @default.
• W2053705516 countsByYear W20537055162013 @default.
• W2053705516 countsByYear W20537055162014 @default.
• W2053705516 countsByYear W20537055162015 @default.
• W2053705516 countsByYear W20537055162018 @default.
• W2053705516 countsByYear W20537055162019 @default.
• W2053705516 countsByYear W20537055162020 @default.
• W2053705516 countsByYear W20537055162021 @default.
• W2053705516 countsByYear W20537055162023 @default.
• W2053705516 crossrefType "journal-article" @default.
• W2053705516 hasAuthorship W2053705516A5016028400 @default.
• W2053705516 hasAuthorship W2053705516A5034432282 @default.
• W2053705516 hasAuthorship W2053705516A5041694329 @default.
• W2053705516 hasConcept C10146269 @default.
• W2053705516 hasConcept C126322002 @default.
• W2053705516 hasConcept C134018914 @default.
• W2053705516 hasConcept C142724271 @default.
• W2053705516 hasConcept C204787440 @default.
• W2053705516 hasConcept C27081682 @default.
• W2053705516 hasConcept C2776705890 @default.
• W2053705516 hasConcept C2777195454 @default.
• W2053705516 hasConcept C2778288131 @default.
• W2053705516 hasConcept C2993291352 @default.
• W2053705516 hasConcept C526584372 @default.
• W2053705516 hasConcept C59822182 @default.
• W2053705516 hasConcept C71315377 @default.
• W2053705516 hasConcept C71924100 @default.
• W2053705516 hasConcept C86803240 @default.
• W2053705516 hasConceptScore W2053705516C10146269 @default.
• W2053705516 hasConceptScore W2053705516C126322002 @default.
• W2053705516 hasConceptScore W2053705516C134018914 @default.
• W2053705516 hasConceptScore W2053705516C142724271 @default.
• W2053705516 hasConceptScore W2053705516C204787440 @default.
• W2053705516 hasConceptScore W2053705516C27081682 @default.
• W2053705516 hasConceptScore W2053705516C2776705890 @default.
• W2053705516 hasConceptScore W2053705516C2777195454 @default.
• W2053705516 hasConceptScore W2053705516C2778288131 @default.
• W2053705516 hasConceptScore W2053705516C2993291352 @default.
• W2053705516 hasConceptScore W2053705516C526584372 @default.
• W2053705516 hasConceptScore W2053705516C59822182 @default.
• W2053705516 hasConceptScore W2053705516C71315377 @default.
• W2053705516 hasConceptScore W2053705516C71924100 @default.
• W2053705516 hasConceptScore W2053705516C86803240 @default.
• W2053705516 hasIssue "5" @default.
• W2053705516 hasLocation W20537055161 @default.
• W2053705516 hasOpenAccess W2053705516 @default.
• W2053705516 hasPrimaryLocation W20537055161 @default.
• W2053705516 hasRelatedWork W1548669396 @default.
• W2053705516 hasRelatedWork W1981780460 @default.
• W2053705516 hasRelatedWork W1987782885 @default.
• W2053705516 hasRelatedWork W1988507778 @default.
• W2053705516 hasRelatedWork W2055601973 @default.
• W2053705516 hasRelatedWork W2066485846 @default.
• W2053705516 hasRelatedWork W2083970607 @default.
• W2053705516 hasRelatedWork W2106532285 @default.
• W2053705516 hasRelatedWork W2123776185 @default.
• W2053705516 hasRelatedWork W851836452 @default.
• W2053705516 hasVolume "9" @default.
• W2053705516 isParatext "false" @default.
• W2053705516 isRetracted "false" @default.
• W2053705516 magId "2053705516" @default.
• W2053705516 workType "article" @default.