Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053705840> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2053705840 abstract "Photodynamic treatment that causes intense oxidative stress and kills cells is currently used in neurooncology. However, along with tumor it damages surrounding healthy neurons and glial cells. In order to study the possible role of glutamate-related signaling pathways in photodynamic injury of neurons and glia, we investigated photodynamic effect of alumophthalocyanine Photosens on isolated crayfish stretch receptor that consists of a single neuron surrounded by glial cells. The laser diode (670 nm, 0.4 W/cm<sup>2</sup>) was used for dye photoexcitation. Application of glutamate increased photodynamically induced necrosis of neurons and glial cells but significantly decreased glial apoptosis. The natural neuroglial mediator N-acetylaspartylglutamate, which releases glutamate after cleavage in the extracellular space by glutamate carboxypeptidase II, also inhibited photoinduced apoptosis. Inhibition of glutamate carboxypeptidase II, oppositely, enhanced apoptosis of glial cells. These data confirm the anti-apoptotic activity of glutamate. Application of NMDA or inhibition of NMDA receptors by MK801 did not influence photodynamic death of neurons and glial cells that indicated nonparticipation of NMDA receptors in these processes. Inhibition of metabotropic glutamate receptors by AP-3 decreased PDT-induced apoptosis. One can suggest that crayfish neurons naturally secrete NAAG, which being cleaved by GCOP produces glutamate. Glutamate prevents photoinduced apoptosis of glial cells possibly through metabotropic but not ionotropic glutamate receptors." @default.
- W2053705840 created "2016-06-24" @default.
- W2053705840 creator A5019599459 @default.
- W2053705840 creator A5023647654 @default.
- W2053705840 creator A5025436392 @default.
- W2053705840 creator A5038638299 @default.
- W2053705840 creator A5068349825 @default.
- W2053705840 date "2010-10-22" @default.
- W2053705840 modified "2023-10-10" @default.
- W2053705840 title "Glutamate-mediated protection of crayfish glial cells from PDT-induced apoptosis" @default.
- W2053705840 cites W1601632182 @default.
- W2053705840 cites W1964638346 @default.
- W2053705840 cites W1966327998 @default.
- W2053705840 cites W1967023620 @default.
- W2053705840 cites W1970367133 @default.
- W2053705840 cites W1992270806 @default.
- W2053705840 cites W1997219075 @default.
- W2053705840 cites W2005494498 @default.
- W2053705840 cites W2012699085 @default.
- W2053705840 cites W2016576571 @default.
- W2053705840 cites W2030253522 @default.
- W2053705840 cites W2053042883 @default.
- W2053705840 cites W2066274220 @default.
- W2053705840 cites W2068099086 @default.
- W2053705840 cites W2083679699 @default.
- W2053705840 cites W2090020685 @default.
- W2053705840 cites W2100040827 @default.
- W2053705840 cites W2102532330 @default.
- W2053705840 cites W2115914766 @default.
- W2053705840 cites W2143662283 @default.
- W2053705840 cites W2161214665 @default.
- W2053705840 cites W2405695982 @default.
- W2053705840 cites W3188853332 @default.
- W2053705840 doi "https://doi.org/10.1117/12.889386" @default.
- W2053705840 hasPublicationYear "2010" @default.
- W2053705840 type Work @default.
- W2053705840 sameAs 2053705840 @default.
- W2053705840 citedByCount "0" @default.
- W2053705840 crossrefType "proceedings-article" @default.
- W2053705840 hasAuthorship W2053705840A5019599459 @default.
- W2053705840 hasAuthorship W2053705840A5023647654 @default.
- W2053705840 hasAuthorship W2053705840A5025436392 @default.
- W2053705840 hasAuthorship W2053705840A5038638299 @default.
- W2053705840 hasAuthorship W2053705840A5068349825 @default.
- W2053705840 hasConcept C115955781 @default.
- W2053705840 hasConcept C170493617 @default.
- W2053705840 hasConcept C185592680 @default.
- W2053705840 hasConcept C26702167 @default.
- W2053705840 hasConcept C2781012912 @default.
- W2053705840 hasConcept C41653306 @default.
- W2053705840 hasConcept C49051014 @default.
- W2053705840 hasConcept C55493867 @default.
- W2053705840 hasConcept C61174792 @default.
- W2053705840 hasConcept C67018056 @default.
- W2053705840 hasConcept C86803240 @default.
- W2053705840 hasConcept C95444343 @default.
- W2053705840 hasConceptScore W2053705840C115955781 @default.
- W2053705840 hasConceptScore W2053705840C170493617 @default.
- W2053705840 hasConceptScore W2053705840C185592680 @default.
- W2053705840 hasConceptScore W2053705840C26702167 @default.
- W2053705840 hasConceptScore W2053705840C2781012912 @default.
- W2053705840 hasConceptScore W2053705840C41653306 @default.
- W2053705840 hasConceptScore W2053705840C49051014 @default.
- W2053705840 hasConceptScore W2053705840C55493867 @default.
- W2053705840 hasConceptScore W2053705840C61174792 @default.
- W2053705840 hasConceptScore W2053705840C67018056 @default.
- W2053705840 hasConceptScore W2053705840C86803240 @default.
- W2053705840 hasConceptScore W2053705840C95444343 @default.
- W2053705840 hasLocation W20537058401 @default.
- W2053705840 hasOpenAccess W2053705840 @default.
- W2053705840 hasPrimaryLocation W20537058401 @default.
- W2053705840 hasRelatedWork W153844251 @default.
- W2053705840 hasRelatedWork W2002653194 @default.
- W2053705840 hasRelatedWork W2052733131 @default.
- W2053705840 hasRelatedWork W2098954876 @default.
- W2053705840 hasRelatedWork W2151143028 @default.
- W2053705840 hasRelatedWork W2180195230 @default.
- W2053705840 hasRelatedWork W2357841647 @default.
- W2053705840 hasRelatedWork W2410436264 @default.
- W2053705840 hasRelatedWork W2415755816 @default.
- W2053705840 hasRelatedWork W2264953482 @default.
- W2053705840 isParatext "false" @default.
- W2053705840 isRetracted "false" @default.
- W2053705840 magId "2053705840" @default.
- W2053705840 workType "article" @default.