FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053709592> ?p ?o ?g. }

• W2053709592 endingPage "215" @default.
• W2053709592 startingPage "206" @default.
• W2053709592 abstract "Abstract: Using a modified quantitative reverse transcriptase (RT) PCR assay in 57 patients with acute myeloid leukaemia (AML) from a Swiss Phase III multicentre study (SAKK 30/85), we measured the m-RNA expression of the genes from the multidrug resistance gene 1 (MDR1), the multidrug resistance associated protein (MRP), glutathione-S-transferase (GST) π, bcl-2 and topoisomerase (topo) IIα. P-glycoprotein (p-gp) was measured by Western blot, and GST activity by functional assays. To analyse progression-free (PFS) and overall survival (OS), parameters were prospectively divided into “low” and “high” groups, according to their median values (exceptions: MDR1 and p-gp). Median follow-up was 60 months. Results: MDR1- and MRP mRNA levels correlated with each other (r = 0.54, Spearman), FABM4/M5 and extramedullary disease. “Low” bcl-2-mRNA predicted longer PFS: 22 months vs. 7 months (median, p = 0.02, log rank), and longer OS: 64 months vs. 14 months (p = 0.06). “Low” topo Hoc predicted poorer outcome: median PFS 9 vs. 19 months (p = 0.03); median survival 12 months vs. “not reached” (p = 0.03). An improved outcome tendency, albeit nonsignificant, was seen in p-gp-negative patients. In a Cox model adjusted for age, performance status, presence of Auer rods, FAB type and clinical response, bcl-2 and topo IIα mRNA levels retained their predictive values." @default.
• W2053709592 created "2016-06-24" @default.
• W2053709592 creator A5000513493 @default.
• W2053709592 creator A5001560780 @default.
• W2053709592 creator A5041718737 @default.
• W2053709592 creator A5043046434 @default.
• W2053709592 creator A5049605313 @default.
• W2053709592 creator A5060986576 @default.
• W2053709592 creator A5061189865 @default.
• W2053709592 creator A5082943014 @default.
• W2053709592 creator A5088775074 @default.
• W2053709592 date "2009-04-24" @default.
• W2053709592 modified "2023-10-15" @default.
• W2053709592 title "Five putative drug resistance parameters (MDR1/P-glycoprotein, MDR-associated protein, glutathione-S-transferase, bcl-2 and topoisomerase IIα) in 57 newly diagnosed acute myeloid leukaemias" @default.
• W2053709592 cites W103847125 @default.
• W2053709592 cites W1487506158 @default.
• W2053709592 cites W1898305570 @default.
• W2053709592 cites W1926226751 @default.
• W2053709592 cites W1965353870 @default.
• W2053709592 cites W1975843196 @default.
• W2053709592 cites W1979936660 @default.
• W2053709592 cites W1981545079 @default.
• W2053709592 cites W1989827232 @default.
• W2053709592 cites W2013051826 @default.
• W2053709592 cites W2021402708 @default.
• W2053709592 cites W2024582476 @default.
• W2053709592 cites W2028521588 @default.
• W2053709592 cites W2028834400 @default.
• W2053709592 cites W2028962524 @default.
• W2053709592 cites W2033553519 @default.
• W2053709592 cites W2042165433 @default.
• W2053709592 cites W2058215061 @default.
• W2053709592 cites W2063703890 @default.
• W2053709592 cites W2068561160 @default.
• W2053709592 cites W2073448656 @default.
• W2053709592 cites W2082183799 @default.
• W2053709592 cites W2091271193 @default.
• W2053709592 cites W2101108802 @default.
• W2053709592 cites W2107622792 @default.
• W2053709592 cites W2109492486 @default.
• W2053709592 cites W2136781769 @default.
• W2053709592 cites W2150150931 @default.
• W2053709592 cites W2153712534 @default.
• W2053709592 cites W2159332590 @default.
• W2053709592 cites W2167564928 @default.
• W2053709592 cites W2168070336 @default.
• W2053709592 cites W2257838202 @default.
• W2053709592 cites W2318674152 @default.
• W2053709592 cites W2319148341 @default.
• W2053709592 cites W3111650914 @default.
• W2053709592 cites W4293241248 @default.
• W2053709592 cites W78711663 @default.
• W2053709592 doi "https://doi.org/10.1111/j.1600-0609.1997.tb00979.x" @default.
• W2053709592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9338618" @default.
• W2053709592 hasPublicationYear "2009" @default.
• W2053709592 type Work @default.
• W2053709592 sameAs 2053709592 @default.
• W2053709592 citedByCount "25" @default.
• W2053709592 countsByYear W20537095922012 @default.
• W2053709592 countsByYear W20537095922017 @default.
• W2053709592 countsByYear W20537095922023 @default.
• W2053709592 crossrefType "journal-article" @default.
• W2053709592 hasAuthorship W2053709592A5000513493 @default.
• W2053709592 hasAuthorship W2053709592A5001560780 @default.
• W2053709592 hasAuthorship W2053709592A5041718737 @default.
• W2053709592 hasAuthorship W2053709592A5043046434 @default.
• W2053709592 hasAuthorship W2053709592A5049605313 @default.
• W2053709592 hasAuthorship W2053709592A5060986576 @default.
• W2053709592 hasAuthorship W2053709592A5061189865 @default.
• W2053709592 hasAuthorship W2053709592A5082943014 @default.
• W2053709592 hasAuthorship W2053709592A5088775074 @default.
• W2053709592 hasConcept C114851261 @default.
• W2053709592 hasConcept C126322002 @default.
• W2053709592 hasConcept C133936738 @default.
• W2053709592 hasConcept C147897179 @default.
• W2053709592 hasConcept C181199279 @default.
• W2053709592 hasConcept C203014093 @default.
• W2053709592 hasConcept C2778707650 @default.
• W2053709592 hasConcept C55493867 @default.
• W2053709592 hasConcept C71924100 @default.
• W2053709592 hasConcept C86803240 @default.
• W2053709592 hasConcept C89423630 @default.
• W2053709592 hasConcept C90924648 @default.
• W2053709592 hasConceptScore W2053709592C114851261 @default.
• W2053709592 hasConceptScore W2053709592C126322002 @default.
• W2053709592 hasConceptScore W2053709592C133936738 @default.
• W2053709592 hasConceptScore W2053709592C147897179 @default.
• W2053709592 hasConceptScore W2053709592C181199279 @default.
• W2053709592 hasConceptScore W2053709592C203014093 @default.
• W2053709592 hasConceptScore W2053709592C2778707650 @default.
• W2053709592 hasConceptScore W2053709592C55493867 @default.
• W2053709592 hasConceptScore W2053709592C71924100 @default.
• W2053709592 hasConceptScore W2053709592C86803240 @default.
• W2053709592 hasConceptScore W2053709592C89423630 @default.
• W2053709592 hasConceptScore W2053709592C90924648 @default.
• W2053709592 hasIssue "4" @default.
• W2053709592 hasLocation W20537095921 @default.
• W2053709592 hasLocation W20537095922 @default.

• next