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- W2053711251 abstract "This paper describes design and syntheses of a new class of chelator-type nucleic acid mimics. Four nucleic acid mimics 7, 11, 15, 17 possess a nucleobase and two ethylenediamine moieties for intermolecular metal coordination. We expected that chelator-type nucleic acid mimics formed a strand in the presence of metal ion and then interacted with a single-stranded DNA. Efficient synthetic routes leading to the four nucleic acid analogues have been achieved via the key intermediate compound 5 which was derived from 3,5-dimethylphenol in five steps. Compound 7 was treated with zinc nitrate and Zn complex 8 was isolated as crystals. 1H NMR study of Zn complex 8 in D2O showed the single-strand formation. Job plots showed that mixture of (dT)70 with Zn complex 8 at 5°C reached a minimum absorbance at a mole ratio of 2:1, and the hypochromic effect showed the π–π stacking interaction between the nucleobases. Thermal denaturation study at 2:1 mole ratio of complexes between (dT)70 and Zn complex 8 showed melting point at 27°C." @default.
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- W2053711251 date "2002-04-01" @default.
- W2053711251 modified "2023-10-02" @default.
- W2053711251 title "Syntheses of nucleic acid mimics designed for metal-induced strand formation on DNA" @default.
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- W2053711251 doi "https://doi.org/10.1016/s0040-4020(02)00203-x" @default.
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