FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053722014> ?p ?o ?g. }

• W2053722014 endingPage "5396" @default.
• W2053722014 startingPage "5392" @default.
• W2053722014 abstract "Long-term insulin treatment selectively stimulates secretion of the truncated form of apolipoprotein B (apoB), apoB-48, from primary rat hepatocytes in culture. Chronic treatment with insulin at 400 ng/ml causes a 3-fold increase in total apoB secretion, with apoB-48 making up about 75% of that increase. apo-B-48 is the protein product generated by translation of full-length apoB mRNA which has been modified by a posttranscriptional editing mechanism. Editing changes codon 2153 in the middle of the apoB-100 coding region from CAA, coding for glutamine, to UAA, a translation stop signal. We therefore examined the effect of insulin treatment on the ratio of edited to nonedited apoB mRNA in RNA isolated from primary rat hepatocyte cultures. There was a dramatic shift in the ratio of edited versus nonedited forms of apoB mRNA, from about 1:1 in untreated cells to 7:1 in insulin-treated cells. Insulin exerted a dose-dependent effect on apoB secretion and apoB mRNA editing over the range of insulin concentrations studied (0.4-400 ng/ml). In contrast, oleic acid, which also increased apoB (B-48 and B-100) secretion, had no significant effect on the ratio of apoB-48 to apoB-100 particles secreted and no effect on the proportion of edited apoB mRNA. Neither insulin nor oleic acid affects total apoB mRNA levels as assayed by Northern blot analysis. These data strongly suggest that insulin stimulates biosynthesis and secretion of apoB-48 in rat hepatocytes by regulating the proportion of edited apoB mRNA." @default.
• W2053722014 created "2016-06-24" @default.
• W2053722014 creator A5022692420 @default.
• W2053722014 creator A5025437292 @default.
• W2053722014 creator A5036558176 @default.
• W2053722014 creator A5038437206 @default.
• W2053722014 creator A5053280936 @default.
• W2053722014 creator A5057369366 @default.
• W2053722014 date "1994-06-07" @default.
• W2053722014 modified "2023-10-16" @default.
• W2053722014 title "Insulin promotes the biosynthesis and secretion of apolipoprotein B-48 by altering apolipoprotein B mRNA editing." @default.
• W2053722014 cites W1422748336 @default.
• W2053722014 cites W1555122375 @default.
• W2053722014 cites W1556603878 @default.
• W2053722014 cites W1576034245 @default.
• W2053722014 cites W1579270220 @default.
• W2053722014 cites W1588762192 @default.
• W2053722014 cites W1599366995 @default.
• W2053722014 cites W1658546299 @default.
• W2053722014 cites W1956183677 @default.
• W2053722014 cites W1964558072 @default.
• W2053722014 cites W1970117908 @default.
• W2053722014 cites W1973732415 @default.
• W2053722014 cites W1976607645 @default.
• W2053722014 cites W1986419990 @default.
• W2053722014 cites W2021099198 @default.
• W2053722014 cites W2047710997 @default.
• W2053722014 cites W2069091241 @default.
• W2053722014 cites W2082666006 @default.
• W2053722014 cites W2086258039 @default.
• W2053722014 cites W2087240242 @default.
• W2053722014 cites W2088227793 @default.
• W2053722014 cites W2090595768 @default.
• W2053722014 cites W2096773810 @default.
• W2053722014 cites W2149258475 @default.
• W2053722014 cites W2188563156 @default.
• W2053722014 cites W2345404920 @default.
• W2053722014 cites W236972598 @default.
• W2053722014 cites W2406102766 @default.
• W2053722014 cites W341867865 @default.
• W2053722014 cites W58132180 @default.
• W2053722014 doi "https://doi.org/10.1073/pnas.91.12.5392" @default.
• W2053722014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/44001" @default.
• W2053722014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8202496" @default.
• W2053722014 hasPublicationYear "1994" @default.
• W2053722014 type Work @default.
• W2053722014 sameAs 2053722014 @default.
• W2053722014 citedByCount "57" @default.
• W2053722014 countsByYear W20537220142012 @default.
• W2053722014 countsByYear W20537220142013 @default.
• W2053722014 countsByYear W20537220142014 @default.
• W2053722014 countsByYear W20537220142018 @default.
• W2053722014 crossrefType "journal-article" @default.
• W2053722014 hasAuthorship W2053722014A5022692420 @default.
• W2053722014 hasAuthorship W2053722014A5025437292 @default.
• W2053722014 hasAuthorship W2053722014A5036558176 @default.
• W2053722014 hasAuthorship W2053722014A5038437206 @default.
• W2053722014 hasAuthorship W2053722014A5053280936 @default.
• W2053722014 hasAuthorship W2053722014A5057369366 @default.
• W2053722014 hasBestOaLocation W20537220142 @default.
• W2053722014 hasConcept C104317684 @default.
• W2053722014 hasConcept C105580179 @default.
• W2053722014 hasConcept C126322002 @default.
• W2053722014 hasConcept C134018914 @default.
• W2053722014 hasConcept C153911025 @default.
• W2053722014 hasConcept C185592680 @default.
• W2053722014 hasConcept C2778163477 @default.
• W2053722014 hasConcept C2779306644 @default.
• W2053722014 hasConcept C49039625 @default.
• W2053722014 hasConcept C55493867 @default.
• W2053722014 hasConcept C62746215 @default.
• W2053722014 hasConcept C71924100 @default.
• W2053722014 hasConcept C86803240 @default.
• W2053722014 hasConceptScore W2053722014C104317684 @default.
• W2053722014 hasConceptScore W2053722014C105580179 @default.
• W2053722014 hasConceptScore W2053722014C126322002 @default.
• W2053722014 hasConceptScore W2053722014C134018914 @default.
• W2053722014 hasConceptScore W2053722014C153911025 @default.
• W2053722014 hasConceptScore W2053722014C185592680 @default.
• W2053722014 hasConceptScore W2053722014C2778163477 @default.
• W2053722014 hasConceptScore W2053722014C2779306644 @default.
• W2053722014 hasConceptScore W2053722014C49039625 @default.
• W2053722014 hasConceptScore W2053722014C55493867 @default.
• W2053722014 hasConceptScore W2053722014C62746215 @default.
• W2053722014 hasConceptScore W2053722014C71924100 @default.
• W2053722014 hasConceptScore W2053722014C86803240 @default.
• W2053722014 hasIssue "12" @default.
• W2053722014 hasLocation W20537220141 @default.
• W2053722014 hasLocation W20537220142 @default.
• W2053722014 hasLocation W20537220143 @default.
• W2053722014 hasLocation W20537220144 @default.
• W2053722014 hasOpenAccess W2053722014 @default.
• W2053722014 hasPrimaryLocation W20537220141 @default.
• W2053722014 hasRelatedWork W1983641721 @default.
• W2053722014 hasRelatedWork W1995945960 @default.
• W2053722014 hasRelatedWork W2026226896 @default.
• W2053722014 hasRelatedWork W2041678535 @default.
• W2053722014 hasRelatedWork W2066345847 @default.

• next