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• W2053732127 abstract "Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an X-linked genetic component. Recent studies have identified an X chromosomal susceptibility region (Xq24-q28) in two typical migraine pedigrees. This region harbours a potential candidate gene for the disorder, the serotonin receptor 2C (5-HT(2C)) gene. This study involved a linkage and association approach to investigate two single nucleotide variants in the 5-HT(2C) gene. In addition, exonic coding regions of the 5-HT(2C) gene were also sequenced for mutations in X-linked migraine pedigrees. Results of this study did not detect any linkage or association, and no disease causing mutations were identified. Hence, results for this study do not support a significant role of the 5-HT(2C) gene in migraine predisposition." @default.
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• W2053732127 date "2003-01-28" @default.
• W2053732127 modified "2023-09-24" @default.
• W2053732127 title "An investigation of the5-HT2C receptor gene as a migraine candidate gene" @default.
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• W2053732127 doi "https://doi.org/10.1002/ajmg.b.10007" @default.
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