FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053745385> ?p ?o ?g. }

• W2053745385 abstract "Transcription activator-like effector (TALE) nuclease (TALEN) is a site-specific nuclease, which can be freely designed and easily constructed. Numerous methods of constructing TALENs harboring different TALE scaffolds and repeat variants have recently been reported. However, the functionalities of structurally different TALENs have not yet been compared. Here, we report on the functional differences among several types of TALENs targeting the same loci. Using HEK293T cell-based single-strand annealing and Cel-I nuclease assays, we found that TALENs with periodically-patterned repeat variants harboring non-repeat-variable di-residue (non-RVD) variations (Platinum TALENs) showed higher activities than TALENs without non-RVD variations. Furthermore, the efficiencies of gene disruption mediated by Platinum TALENs in frogs and rats were significantly higher than in previous reports. This study therefore demonstrated an efficient system for the construction of these highly active Platinum TALENs (Platinum Gate system), which could establish a new standard in TALEN engineering." @default.
• W2053745385 created "2016-06-24" @default.
• W2053745385 creator A5026826873 @default.
• W2053745385 creator A5039480645 @default.
• W2053745385 creator A5042133994 @default.
• W2053745385 creator A5044932170 @default.
• W2053745385 creator A5047004566 @default.
• W2053745385 creator A5047866215 @default.
• W2053745385 creator A5048938769 @default.
• W2053745385 creator A5063734833 @default.
• W2053745385 creator A5065319313 @default.
• W2053745385 creator A5078140561 @default.
• W2053745385 creator A5090897062 @default.
• W2053745385 date "2013-11-29" @default.
• W2053745385 modified "2023-09-27" @default.
• W2053745385 title "Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity" @default.
• W2053745385 cites W1909302925 @default.
• W2053745385 cites W1963704787 @default.
• W2053745385 cites W1964058953 @default.
• W2053745385 cites W1966198395 @default.
• W2053745385 cites W1970549334 @default.
• W2053745385 cites W1976508887 @default.
• W2053745385 cites W1980556586 @default.
• W2053745385 cites W1981540403 @default.
• W2053745385 cites W1999068651 @default.
• W2053745385 cites W2002767268 @default.
• W2053745385 cites W2008553597 @default.
• W2053745385 cites W2013253012 @default.
• W2053745385 cites W2025074364 @default.
• W2053745385 cites W2036104419 @default.
• W2053745385 cites W2052982315 @default.
• W2053745385 cites W2068166332 @default.
• W2053745385 cites W2087264052 @default.
• W2053745385 cites W2099861099 @default.
• W2053745385 cites W2117364468 @default.
• W2053745385 cites W2129415133 @default.
• W2053745385 cites W2130931930 @default.
• W2053745385 cites W2133704193 @default.
• W2053745385 cites W2137209165 @default.
• W2053745385 cites W2138231299 @default.
• W2053745385 cites W2151611659 @default.
• W2053745385 cites W2168245648 @default.
• W2053745385 cites W2168487117 @default.
• W2053745385 cites W43229842 @default.
• W2053745385 doi "https://doi.org/10.1038/srep03379" @default.
• W2053745385 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3843162" @default.
• W2053745385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24287550" @default.
• W2053745385 hasPublicationYear "2013" @default.
• W2053745385 type Work @default.
• W2053745385 sameAs 2053745385 @default.
• W2053745385 citedByCount "184" @default.
• W2053745385 countsByYear W20537453852013 @default.
• W2053745385 countsByYear W20537453852014 @default.
• W2053745385 countsByYear W20537453852015 @default.
• W2053745385 countsByYear W20537453852016 @default.
• W2053745385 countsByYear W20537453852017 @default.
• W2053745385 countsByYear W20537453852018 @default.
• W2053745385 countsByYear W20537453852019 @default.
• W2053745385 countsByYear W20537453852020 @default.
• W2053745385 countsByYear W20537453852021 @default.
• W2053745385 countsByYear W20537453852022 @default.
• W2053745385 countsByYear W20537453852023 @default.
• W2053745385 crossrefType "journal-article" @default.
• W2053745385 hasAuthorship W2053745385A5026826873 @default.
• W2053745385 hasAuthorship W2053745385A5039480645 @default.
• W2053745385 hasAuthorship W2053745385A5042133994 @default.
• W2053745385 hasAuthorship W2053745385A5044932170 @default.
• W2053745385 hasAuthorship W2053745385A5047004566 @default.
• W2053745385 hasAuthorship W2053745385A5047866215 @default.
• W2053745385 hasAuthorship W2053745385A5048938769 @default.
• W2053745385 hasAuthorship W2053745385A5063734833 @default.
• W2053745385 hasAuthorship W2053745385A5065319313 @default.
• W2053745385 hasAuthorship W2053745385A5078140561 @default.
• W2053745385 hasAuthorship W2053745385A5090897062 @default.
• W2053745385 hasBestOaLocation W20537453851 @default.
• W2053745385 hasConcept C104317684 @default.
• W2053745385 hasConcept C141231307 @default.
• W2053745385 hasConcept C144501496 @default.
• W2053745385 hasConcept C2777271071 @default.
• W2053745385 hasConcept C31909778 @default.
• W2053745385 hasConcept C51785407 @default.
• W2053745385 hasConcept C54355233 @default.
• W2053745385 hasConcept C552990157 @default.
• W2053745385 hasConcept C70721500 @default.
• W2053745385 hasConcept C86803240 @default.
• W2053745385 hasConcept C95444343 @default.
• W2053745385 hasConceptScore W2053745385C104317684 @default.
• W2053745385 hasConceptScore W2053745385C141231307 @default.
• W2053745385 hasConceptScore W2053745385C144501496 @default.
• W2053745385 hasConceptScore W2053745385C2777271071 @default.
• W2053745385 hasConceptScore W2053745385C31909778 @default.
• W2053745385 hasConceptScore W2053745385C51785407 @default.
• W2053745385 hasConceptScore W2053745385C54355233 @default.
• W2053745385 hasConceptScore W2053745385C552990157 @default.
• W2053745385 hasConceptScore W2053745385C70721500 @default.
• W2053745385 hasConceptScore W2053745385C86803240 @default.
• W2053745385 hasConceptScore W2053745385C95444343 @default.
• W2053745385 hasIssue "1" @default.
• W2053745385 hasLocation W20537453851 @default.
• W2053745385 hasLocation W20537453852 @default.

• next