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- W2053751036 abstract "A radiation-sensitive strain (Bs-1) of Escherichia coli B and a radiation-resistant strain (B/r) were irradiated with ultraviolet light. Low doses (5 to 20 ergs/mm2 at 2650 Å) completely inhibit DNA synthesis in Bs-1, and synthesis is not resumed. A mathematical model is developed in which a pyrimidine dimer is a block to DNA synthesis. The experimental data for Bs-1 fit the model if a dimer every 200 μ (20% of the length of the E. coli chromosome) blocks synthesis. When DNA synthesis in B/r is blocked by larger doses of ultraviolet (50 to 200 ergs per mm2 at 2650 Å), it is resumed after a lag period during which pyrimidine dimers are excised from the DNA. Holding these cells in non-nutrient medium shortens the lag period, and the decrease in lag period is correlated with the excision of pyrimidine dimers. Chloramphenicol, an inhibitor of protein synthesis, does not affect dimer excision in B/r, and DNA synthesis is resumed at the same time in irradiated cells with or without the inhibitor. In both Bs-1 and B/r, irradiation at 2650 Å is most efficient in blocking DNA synthesis. Inhibition of DNA synthesis can be photoreactivated in both strains, but if photoreactivating light is given after Bs-1 cells are allowed to polymerize up to a block, the amount of photoreactivation is greatly reduced. RNA and protein synthesis in unirradiated growing cells increase exponentially, together with DNA synthesis, but when DNA synthesis is blocked by ultraviolet irradiation in either strain, RNA and protein synthesis are linear. When DNA synthesis is resumed in B/r, RNA and protein increase exponentially. The results are consistent with current ideas on the relationships among DNA, RNA and protein, and with the interpretation that pyrimidine dimers are blocks to DNA synthesis." @default.
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- W2053751036 date "1982-09-01" @default.
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- W2053751036 title "Studies on the effects of radiation on cyanobacteria" @default.
- W2053751036 doi "https://doi.org/10.1016/0027-5107(82)90041-0" @default.
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