FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053753640> ?p ?o ?g. }

• W2053753640 endingPage "2274" @default.
• W2053753640 startingPage "2261" @default.
• W2053753640 abstract "To evaluate how a more flexible and thorough multiobjective search of feasible IMRT plans affects performance in IMRT optimization.A multiobjective evolutionary algorithm (MOEA) was used as a tool to investigate how expanding the search space to include a wider range of penalty functions affects the quality of the set of IMRT plans produced. The MOEA uses a population of IMRT plans to generate new IMRT plans through deterministic minimization of recombined penalty functions that are weighted sums of multiple, tissue-specific objective functions. The quality of the generated plans are judged by an independent set of nonconvex, clinically relevant decision criteria, and all dominated plans are eliminated. As this process repeats itself, better plans are produced so that the population of IMRT plans will approach the Pareto front. Three different approaches were used to explore the effects of expanding the search space. First, the evolutionary algorithm used genetic optimization principles to search by simultaneously optimizing both the weights and tissue-specific dose parameters in penalty functions. Second, penalty function parameters were individually optimized for each voxel in all organs at risk (OARs) in the MOEA. Finally, a heuristic voxel-specific improvement (VSI) algorithm that can be used on any IMRT plan was developed that incrementally improves voxel-specific penalty function parameters for all structures (OARs and targets). Different approaches were compared using the concept of domination comparison applied to the sets of plans obtained by multiobjective optimization.MOEA optimizations that simultaneously searched both importance weights and dose parameters generated sets of IMRT plans that were superior to sets of plans produced when either type of parameter was fixed for four example prostate plans. The amount of improvement increased with greater overlap between OARs and targets. Allowing the MOEA to search for voxel-specific penalty functions improved results for simple cases with three structures but did not improve results for a more complex case with seven structures. For this modification, the amount of improvement increased with less overlap between OARs and targets. The voxel-specific improvement algorithm improved results for all cases, and its clinical relevance was demonstrated in a complex prostate and a very complex head and neck case.Using an evolutionary algorithm as a tool, it was found that allowing more flexibility in the search space enhanced performance. The two strategies of (a) varying the weights and reference doses in the objective function and (b) removing the constraint of equal penalties for all voxels in a structure both generated sets of plans that dominated sets of plans considered to be Pareto optimal within the conventional, more limited search space. When considering voxel-specific objectives, the very large search space can lead to convergence problems in the MOEA for complex cases, but this is not an issue for the VSI algorithm." @default.
• W2053753640 created "2016-06-24" @default.
• W2053753640 creator A5040250492 @default.
• W2053753640 creator A5045139134 @default.
• W2053753640 creator A5055033005 @default.
• W2053753640 creator A5087499481 @default.
• W2053753640 date "2012-04-01" @default.
• W2053753640 modified "2023-10-08" @default.
• W2053753640 title "The use of a multiobjective evolutionary algorithm to increase flexibility in the search for better IMRT plans" @default.
• W2053753640 cites W1965842941 @default.
• W2053753640 cites W1977060865 @default.
• W2053753640 cites W1977459187 @default.
• W2053753640 cites W1979015599 @default.
• W2053753640 cites W1980956836 @default.
• W2053753640 cites W1989099434 @default.
• W2053753640 cites W1997807465 @default.
• W2053753640 cites W2011449126 @default.
• W2053753640 cites W2015602044 @default.
• W2053753640 cites W2021658156 @default.
• W2053753640 cites W2026238687 @default.
• W2053753640 cites W2035629892 @default.
• W2053753640 cites W2036575335 @default.
• W2053753640 cites W2056642298 @default.
• W2053753640 cites W2068943445 @default.
• W2053753640 cites W2099210524 @default.
• W2053753640 cites W2101689005 @default.
• W2053753640 cites W2116622921 @default.
• W2053753640 cites W2149552113 @default.
• W2053753640 cites W2159729510 @default.
• W2053753640 doi "https://doi.org/10.1118/1.3697535" @default.
• W2053753640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3337665" @default.
• W2053753640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22482647" @default.
• W2053753640 hasPublicationYear "2012" @default.
• W2053753640 type Work @default.
• W2053753640 sameAs 2053753640 @default.
• W2053753640 citedByCount "32" @default.
• W2053753640 countsByYear W20537536402012 @default.
• W2053753640 countsByYear W20537536402013 @default.
• W2053753640 countsByYear W20537536402014 @default.
• W2053753640 countsByYear W20537536402015 @default.
• W2053753640 countsByYear W20537536402016 @default.
• W2053753640 countsByYear W20537536402017 @default.
• W2053753640 countsByYear W20537536402018 @default.
• W2053753640 countsByYear W20537536402020 @default.
• W2053753640 countsByYear W20537536402021 @default.
• W2053753640 countsByYear W20537536402022 @default.
• W2053753640 countsByYear W20537536402023 @default.
• W2053753640 crossrefType "journal-article" @default.
• W2053753640 hasAuthorship W2053753640A5040250492 @default.
• W2053753640 hasAuthorship W2053753640A5045139134 @default.
• W2053753640 hasAuthorship W2053753640A5055033005 @default.
• W2053753640 hasAuthorship W2053753640A5087499481 @default.
• W2053753640 hasBestOaLocation W20537536402 @default.
• W2053753640 hasConcept C105795698 @default.
• W2053753640 hasConcept C11413529 @default.
• W2053753640 hasConcept C126255220 @default.
• W2053753640 hasConcept C14036430 @default.
• W2053753640 hasConcept C159149176 @default.
• W2053753640 hasConcept C173801870 @default.
• W2053753640 hasConcept C177264268 @default.
• W2053753640 hasConcept C199360897 @default.
• W2053753640 hasConcept C2780598303 @default.
• W2053753640 hasConcept C2908647359 @default.
• W2053753640 hasConcept C33923547 @default.
• W2053753640 hasConcept C41008148 @default.
• W2053753640 hasConcept C6180225 @default.
• W2053753640 hasConcept C68781425 @default.
• W2053753640 hasConcept C71924100 @default.
• W2053753640 hasConcept C78458016 @default.
• W2053753640 hasConcept C86803240 @default.
• W2053753640 hasConcept C8880873 @default.
• W2053753640 hasConcept C99454951 @default.
• W2053753640 hasConceptScore W2053753640C105795698 @default.
• W2053753640 hasConceptScore W2053753640C11413529 @default.
• W2053753640 hasConceptScore W2053753640C126255220 @default.
• W2053753640 hasConceptScore W2053753640C14036430 @default.
• W2053753640 hasConceptScore W2053753640C159149176 @default.
• W2053753640 hasConceptScore W2053753640C173801870 @default.
• W2053753640 hasConceptScore W2053753640C177264268 @default.
• W2053753640 hasConceptScore W2053753640C199360897 @default.
• W2053753640 hasConceptScore W2053753640C2780598303 @default.
• W2053753640 hasConceptScore W2053753640C2908647359 @default.
• W2053753640 hasConceptScore W2053753640C33923547 @default.
• W2053753640 hasConceptScore W2053753640C41008148 @default.
• W2053753640 hasConceptScore W2053753640C6180225 @default.
• W2053753640 hasConceptScore W2053753640C68781425 @default.
• W2053753640 hasConceptScore W2053753640C71924100 @default.
• W2053753640 hasConceptScore W2053753640C78458016 @default.
• W2053753640 hasConceptScore W2053753640C86803240 @default.
• W2053753640 hasConceptScore W2053753640C8880873 @default.
• W2053753640 hasConceptScore W2053753640C99454951 @default.
• W2053753640 hasFunder F4320332161 @default.
• W2053753640 hasIssue "4" @default.
• W2053753640 hasLocation W20537536401 @default.
• W2053753640 hasLocation W20537536402 @default.
• W2053753640 hasLocation W20537536403 @default.
• W2053753640 hasLocation W20537536404 @default.
• W2053753640 hasOpenAccess W2053753640 @default.

• next