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- W2053756370 abstract "Gag-CD8+ T cell responses are associated with immune control of HIV infection. Since during HIV infection Nef impairs T cell responses, we evaluated whether deletion of nef from a non-infectious HIV DNA vaccine (Δ4 Nef(+)), creating Δ5 Nef(−), would affect its immunogenicity. When compared with Δ4, mice injected with Δ5 developed significantly lower CD8+ T cell responses to Gag, but no significant change in the responses to Env was observed. In vitro, deletion of Nef abrogated the induced cell death, production of virus-like particles and release of Gag from transfected cells. Thus, the effect of Nef in causing extrusion of Gag might adjuvant the CD8+ T cell responses to Gag in DNA vaccine." @default.
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- W2053756370 date "2008-07-01" @default.
- W2053756370 modified "2023-10-18" @default.
- W2053756370 title "Nef modulates the immunogenicity of Gag encoded in a non-infectious HIV DNA vaccine" @default.
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- W2053756370 doi "https://doi.org/10.1016/j.vaccine.2008.05.057" @default.
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