Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053771033> ?p ?o ?g. }
- W2053771033 endingPage "6482" @default.
- W2053771033 startingPage "6469" @default.
- W2053771033 abstract "Purpose: Currently, only iodine- and barium-based contrast media (CM) are used in clinical contrast-enhanced computed tomography (CE-CT). High-Z metals would produce a higher contrast at equal mass density for the x-ray spectra used in clinical CT. Using such materials might allow for significant dose reductions in CE-CT. The purpose of this study was to quantify the potential for dose reduction when using CM based on heavy metals.Methods: The contrast-to-noise ratio weighted by dose (CNRD) was determined as a function of scan protocol by means of measurements and simulations on a clinical CT scanner. For simulations, water cylinders with diameters 160, 320, 480, and 640 mm were used to cover a broad range of patient sizes. Measurements were conducted with 160 and 320 mm water-equivalent plastic cylinders. A central bore of 13 mm diameter was present in all phantoms. The tube voltage was varied from 80 to 140 kV for measurements and from 60 to 180 kV for simulations. Additional tin filtration of thicknesses 0.4, 0.8, and 1.2 mm was applied in the simulation to evaluate a range of spectral hardness. The bore was filled with a mixture of water and 10 mg/ml of pure iodine, holmium, gadolinium, ytterbium, osmium, tungsten, gold, and bismuth for the simulations and with aqueous solutions of ytterbium, tungsten, gold, and bismuth salts as well as Iopromid containing 10 mg/ml of the pure materials for the measurements. CNRDs were compared to iodine at phantom size-dependent reference voltages for all high-Z materials and the resulting dose reduction was calculated for equal contrast-to-noise ratio.Results: Dose reduction potentials strongly depended on phantom size, spectral hardness, and tube voltage. Depending on the added filtration, a dose reduction of 19%–60% could be reached at 80 kV with gadolinium for the 160 mm phantom, 52%–69% at 100 kV with holmium for the 320 mm phantom, 62%–78% with 120 kV for hafnium and the 480 mm phantom and 74%–86% with 140 kV for gold and the 640 mm phantom. While gadolinium might be considered at 160 mm diameter, hafnium showed the best overall performance for phantom sizes of 320 mm and above. The measurements conducted on the clinical CT scanner showed very good agreement with simulations with deviations in the order of 5 to 10%.Conclusions: The results of this study encourage the development and use of CM based on high-Z materials, especially for adipose patients, where high tube voltages are necessary to reach sufficiently short scan times. Hafnium proved to be the best compromise for average-size and for adipose patients. Even higher-Z materials such as gold and bismuth showed a good overall performance in conjunction with high tube voltage, large patients or strong added filtration and may be recommended for scans under these conditions." @default.
- W2053771033 created "2016-06-24" @default.
- W2053771033 creator A5004656468 @default.
- W2053771033 creator A5021947113 @default.
- W2053771033 creator A5023546040 @default.
- W2053771033 creator A5068954016 @default.
- W2053771033 creator A5075515923 @default.
- W2053771033 date "2011-11-14" @default.
- W2053771033 modified "2023-09-26" @default.
- W2053771033 title "Potential of high-Z contrast agents in clinical contrast-enhanced computed tomography" @default.
- W2053771033 cites W1482803442 @default.
- W2053771033 cites W1964728954 @default.
- W2053771033 cites W1969694469 @default.
- W2053771033 cites W1981418870 @default.
- W2053771033 cites W1985699811 @default.
- W2053771033 cites W2000209233 @default.
- W2053771033 cites W2005399374 @default.
- W2053771033 cites W2023491148 @default.
- W2053771033 cites W2032002954 @default.
- W2053771033 cites W2065182922 @default.
- W2053771033 cites W2066140474 @default.
- W2053771033 cites W2072778353 @default.
- W2053771033 cites W2076677600 @default.
- W2053771033 cites W2076769203 @default.
- W2053771033 cites W2105050495 @default.
- W2053771033 cites W2117242020 @default.
- W2053771033 cites W2121421475 @default.
- W2053771033 cites W2134326473 @default.
- W2053771033 cites W2139727647 @default.
- W2053771033 cites W2155232982 @default.
- W2053771033 cites W2155375015 @default.
- W2053771033 cites W2157812230 @default.
- W2053771033 cites W4255694083 @default.
- W2053771033 doi "https://doi.org/10.1118/1.3658738" @default.
- W2053771033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22149830" @default.
- W2053771033 hasPublicationYear "2011" @default.
- W2053771033 type Work @default.
- W2053771033 sameAs 2053771033 @default.
- W2053771033 citedByCount "52" @default.
- W2053771033 countsByYear W20537710332012 @default.
- W2053771033 countsByYear W20537710332013 @default.
- W2053771033 countsByYear W20537710332014 @default.
- W2053771033 countsByYear W20537710332015 @default.
- W2053771033 countsByYear W20537710332016 @default.
- W2053771033 countsByYear W20537710332017 @default.
- W2053771033 countsByYear W20537710332018 @default.
- W2053771033 countsByYear W20537710332019 @default.
- W2053771033 countsByYear W20537710332020 @default.
- W2053771033 countsByYear W20537710332021 @default.
- W2053771033 countsByYear W20537710332022 @default.
- W2053771033 countsByYear W20537710332023 @default.
- W2053771033 crossrefType "journal-article" @default.
- W2053771033 hasAuthorship W2053771033A5004656468 @default.
- W2053771033 hasAuthorship W2053771033A5021947113 @default.
- W2053771033 hasAuthorship W2053771033A5023546040 @default.
- W2053771033 hasAuthorship W2053771033A5068954016 @default.
- W2053771033 hasAuthorship W2053771033A5075515923 @default.
- W2053771033 hasConcept C104293457 @default.
- W2053771033 hasConcept C113196181 @default.
- W2053771033 hasConcept C185592680 @default.
- W2053771033 hasConcept C191897082 @default.
- W2053771033 hasConcept C192562407 @default.
- W2053771033 hasConcept C2989005 @default.
- W2053771033 hasConcept C43617362 @default.
- W2053771033 hasConcept C533668322 @default.
- W2053771033 hasConcept C539932907 @default.
- W2053771033 hasConcept C557651011 @default.
- W2053771033 hasConcept C71924100 @default.
- W2053771033 hasConceptScore W2053771033C104293457 @default.
- W2053771033 hasConceptScore W2053771033C113196181 @default.
- W2053771033 hasConceptScore W2053771033C185592680 @default.
- W2053771033 hasConceptScore W2053771033C191897082 @default.
- W2053771033 hasConceptScore W2053771033C192562407 @default.
- W2053771033 hasConceptScore W2053771033C2989005 @default.
- W2053771033 hasConceptScore W2053771033C43617362 @default.
- W2053771033 hasConceptScore W2053771033C533668322 @default.
- W2053771033 hasConceptScore W2053771033C539932907 @default.
- W2053771033 hasConceptScore W2053771033C557651011 @default.
- W2053771033 hasConceptScore W2053771033C71924100 @default.
- W2053771033 hasIssue "12" @default.
- W2053771033 hasLocation W20537710331 @default.
- W2053771033 hasLocation W20537710332 @default.
- W2053771033 hasOpenAccess W2053771033 @default.
- W2053771033 hasPrimaryLocation W20537710331 @default.
- W2053771033 hasRelatedWork W2085913404 @default.
- W2053771033 hasRelatedWork W2185080621 @default.
- W2053771033 hasRelatedWork W2361408615 @default.
- W2053771033 hasRelatedWork W2364224752 @default.
- W2053771033 hasRelatedWork W2518322564 @default.
- W2053771033 hasRelatedWork W2580596720 @default.
- W2053771033 hasRelatedWork W2587655474 @default.
- W2053771033 hasRelatedWork W2723042891 @default.
- W2053771033 hasRelatedWork W2790248310 @default.
- W2053771033 hasRelatedWork W4281554586 @default.
- W2053771033 hasVolume "38" @default.
- W2053771033 isParatext "false" @default.
- W2053771033 isRetracted "false" @default.
- W2053771033 magId "2053771033" @default.