FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053773140> ?p ?o ?g. }

• W2053773140 endingPage "1648" @default.
• W2053773140 startingPage "1645" @default.
• W2053773140 abstract "The metastasis-associated protein S100A4 promotes the progression of cancer by regulating the remodelling of the extracellular matrix. The expression of S100A4 in vivo is shown and the functional role of S100A4 in the pathogenesis of osteoarthritis and rheumatoid arthritisis is explored. The expression of S100A4 in rheumatoid arthritis, osteoarthritis and normal synovial tissues was determined by immunohistochemistry. The expression of matrix metalloproteinase (MMP) mRNA was measured in rheumatoid arthritis and osteoarthritis synovial fibroblasts treated and untreated with S100A4 oligomer by real-time polymerase chain reaction. Levels of released MMPs were confirmed by ELISA in cell culture supernatants. S100A4 protein was expressed in rheumatoid arthritis and osteoarthritis synovial tissues, in contrast with normal synovium. S100A4 up regulated MMP-3 mRNA in rheumatoid arthritis synovial fluid, with a peak after 6 h. This resulted in release of MMP-3 protein. MMP-1, MMP-9 and MMP-13 mRNA were also up regulated in synovial fluid, but with different kinetics. MMP-14 mRNA showed no change. Thus, S100A4 protein is expressed in synovial tissues of patients with rheumatoid arthritis and osteoarthritis in contrast with healthy people. It induces the expression and release of MMP-3 and other MMPs from synovial fluid. The data suggest that S100A4-producing cells could be involved in the pathogenesis of osteoarthritis and rheumatoid arthritis, including pannus formation and joint destruction." @default.
• W2053773140 created "2016-06-24" @default.
• W2053773140 creator A5000081520 @default.
• W2053773140 creator A5002575151 @default.
• W2053773140 creator A5031588644 @default.
• W2053773140 creator A5068188519 @default.
• W2053773140 creator A5071960589 @default.
• W2053773140 creator A5073770232 @default.
• W2053773140 creator A5089477356 @default.
• W2053773140 date "2006-05-25" @default.
• W2053773140 modified "2023-09-25" @default.
• W2053773140 title "S100A4 is expressed at site of invasion in rheumatoid arthritis synovium and modulates production of matrix metalloproteinases" @default.
• W2053773140 cites W1505763719 @default.
• W2053773140 cites W1606061703 @default.
• W2053773140 cites W1971668218 @default.
• W2053773140 cites W1975071038 @default.
• W2053773140 cites W1985021590 @default.
• W2053773140 cites W2003012091 @default.
• W2053773140 cites W2035666161 @default.
• W2053773140 cites W2049920293 @default.
• W2053773140 cites W2053534299 @default.
• W2053773140 cites W2065140692 @default.
• W2053773140 cites W2079594074 @default.
• W2053773140 cites W2083684518 @default.
• W2053773140 cites W2112603318 @default.
• W2053773140 cites W2141342518 @default.
• W2053773140 cites W2397173338 @default.
• W2053773140 doi "https://doi.org/10.1136/ard.2005.047704" @default.
• W2053773140 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1798462" @default.
• W2053773140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17105852" @default.
• W2053773140 hasPublicationYear "2006" @default.
• W2053773140 type Work @default.
• W2053773140 sameAs 2053773140 @default.
• W2053773140 citedByCount "72" @default.
• W2053773140 countsByYear W20537731402012 @default.
• W2053773140 countsByYear W20537731402013 @default.
• W2053773140 countsByYear W20537731402014 @default.
• W2053773140 countsByYear W20537731402015 @default.
• W2053773140 countsByYear W20537731402016 @default.
• W2053773140 countsByYear W20537731402017 @default.
• W2053773140 countsByYear W20537731402018 @default.
• W2053773140 countsByYear W20537731402019 @default.
• W2053773140 countsByYear W20537731402020 @default.
• W2053773140 countsByYear W20537731402021 @default.
• W2053773140 countsByYear W20537731402023 @default.
• W2053773140 crossrefType "journal-article" @default.
• W2053773140 hasAuthorship W2053773140A5000081520 @default.
• W2053773140 hasAuthorship W2053773140A5002575151 @default.
• W2053773140 hasAuthorship W2053773140A5031588644 @default.
• W2053773140 hasAuthorship W2053773140A5068188519 @default.
• W2053773140 hasAuthorship W2053773140A5071960589 @default.
• W2053773140 hasAuthorship W2053773140A5073770232 @default.
• W2053773140 hasAuthorship W2053773140A5089477356 @default.
• W2053773140 hasBestOaLocation W20537731401 @default.
• W2053773140 hasConcept C109523444 @default.
• W2053773140 hasConcept C126322002 @default.
• W2053773140 hasConcept C142724271 @default.
• W2053773140 hasConcept C189165786 @default.
• W2053773140 hasConcept C203014093 @default.
• W2053773140 hasConcept C204787440 @default.
• W2053773140 hasConcept C2776164576 @default.
• W2053773140 hasConcept C2776268809 @default.
• W2053773140 hasConcept C2777077863 @default.
• W2053773140 hasConcept C2777575956 @default.
• W2053773140 hasConcept C2777652487 @default.
• W2053773140 hasConcept C2777746085 @default.
• W2053773140 hasConcept C2780942790 @default.
• W2053773140 hasConcept C502942594 @default.
• W2053773140 hasConcept C71924100 @default.
• W2053773140 hasConcept C86803240 @default.
• W2053773140 hasConcept C95444343 @default.
• W2053773140 hasConceptScore W2053773140C109523444 @default.
• W2053773140 hasConceptScore W2053773140C126322002 @default.
• W2053773140 hasConceptScore W2053773140C142724271 @default.
• W2053773140 hasConceptScore W2053773140C189165786 @default.
• W2053773140 hasConceptScore W2053773140C203014093 @default.
• W2053773140 hasConceptScore W2053773140C204787440 @default.
• W2053773140 hasConceptScore W2053773140C2776164576 @default.
• W2053773140 hasConceptScore W2053773140C2776268809 @default.
• W2053773140 hasConceptScore W2053773140C2777077863 @default.
• W2053773140 hasConceptScore W2053773140C2777575956 @default.
• W2053773140 hasConceptScore W2053773140C2777652487 @default.
• W2053773140 hasConceptScore W2053773140C2777746085 @default.
• W2053773140 hasConceptScore W2053773140C2780942790 @default.
• W2053773140 hasConceptScore W2053773140C502942594 @default.
• W2053773140 hasConceptScore W2053773140C71924100 @default.
• W2053773140 hasConceptScore W2053773140C86803240 @default.
• W2053773140 hasConceptScore W2053773140C95444343 @default.
• W2053773140 hasIssue "12" @default.
• W2053773140 hasLocation W20537731401 @default.
• W2053773140 hasLocation W20537731402 @default.
• W2053773140 hasLocation W20537731403 @default.
• W2053773140 hasLocation W20537731404 @default.
• W2053773140 hasOpenAccess W2053773140 @default.
• W2053773140 hasPrimaryLocation W20537731401 @default.
• W2053773140 hasRelatedWork W1981279938 @default.
• W2053773140 hasRelatedWork W1991393819 @default.
• W2053773140 hasRelatedWork W2031482342 @default.

• next