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• W2053774384 abstract "SUMMARY The effect of implantation of trenbolone acetate and oestradiol into lambs soon after birth on the metabolism of alanine in the presence and absence of propionate has been studied in isolated perfused livers obtained from suckling and from ruminating lambs. The effect of butyrate on the metabolism of alanine in the presence and absence of propionate has been studied in livers obtained from the steroid implanted lambs. Glucose production in the presence of alanine by livers from non-implanted suckling lambs was more than 3 times greater than that by livers from non-implanted ruminating lambs. Steroid implantation did not affect alanine uptake by the livers but metabolism within the livers was altered. Significant interactions were observed between the age of the lambs and whether or not they had been implanted with steroids for the rates of net glucose production in the absence of propionate ( P < 0·01) and for the rates of release of urea by the livers in the presence of ( P < 0·05) and absence of propionate ( P < 0–01). Propionate did not affect alanine uptake by livers obtained from either suckling or ruminating lambs, but there was a significant interaction ( P < 0·05) between the age of the lambs and whether or not butyrate was infused, indicating that butyrate depressed alanine uptake by livers obtained from implanted ruminating lambs perfused in the absence of propionate. Despite this depression of alanine uptake the rates of net glucose production and urea production were unchanged, indicating that butyrate modified the metabolism of alanine in the livers of implanted ruminating lambs in that a greater proportion of the alanine carbon taken up must have been converted to glucose. Butyrate stimulated net glucose production in the presence of propionate and alanine in livers from suckling ( P < 0·05) but not ruminating lambs. Butyrate was ketogenic and the release of 3-hydroxybutyrate accounted for 45 and 30% of the carbon taken up as butyrate by livers from suckling and ruminating lambs respectively perfused in the absence of propionate. Propionate was antiketogenic. Propionate inhibited urea formation from alanine by livers from implanted suckling ( P < 0·05) and implanted ruminating ( P < 0·001) lambs. This effect was diminished by the presence of butyrate. Lactate was released in the presence of propionate and accounted for approximately 12–5% of the carbon taken up as propionate. It may be concluded that implantation of lambs with anabolic steroids maintains hepatic gluconeogenesis from alanine at rates more closely resembling those found in younger suckling lambs. The effects of the volatile fatty acids on alanine metabolism are likely to be of physiological significance when sheep are fed diets which result in a markedly altered pattern of rumen fermentation." @default.
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• W2053774384 date "1982-10-01" @default.
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• W2053774384 title "The effect of implantation of anabolic steroids into suckling and ruminating lambs on the metabolism of alanine in livers perfused in the presence or absence of volatile fatty acids" @default.
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• W2053774384 doi "https://doi.org/10.1017/s0021859600030185" @default.
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