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• W2053804592 abstract "The natural product miraziridine A isolated from the marine sponge Theonella aff. mirabilis unifies within one molecule three structurally privileged elements: (i) (2R,3R)-aziridine-2,3-dicarboxylic acid, (ii) (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid (statine), and (iii) (E)-(S)-4-amino-7-guanidino-hept-2-enoic acid (vinylogous arginine). The alignment of them realized in the tetrapetide allows for a simultaneous inhibition of the proteolytic activity of trypsin-like serine proteases, papain-like cysteine proteases, and pepsin-like aspartyl proteases. Therefore, this unique compound represents a blueprint for the design of protease class-spanning inhibitors." @default.
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• W2053804592 date "2004-02-01" @default.
• W2053804592 modified "2023-10-10" @default.
• W2053804592 title "Miraziridine A: natures blueprint towards protease class-spanning inhibitors" @default.
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• W2053804592 doi "https://doi.org/10.1016/j.bmcl.2003.12.030" @default.
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