FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053805265> ?p ?o ?g. }

• W2053805265 endingPage "148" @default.
• W2053805265 startingPage "138" @default.
• W2053805265 abstract "This work was aimed at investigating the utility of near infrared (NIR) spectroscopy for simultaneous in-line quantification of drug and excipients in cohesive powder blends in a bin blender. A model formulation containing micronized chlorpheniramine maleate (microCPM), lactose, microcrystalline cellulose (MCC) and magnesium stearate (MgSt) was selected for the blending study. An optical head comprising a sapphire window mounted on the lid of the bin was used to collect in-line NIR spectral data of the powder blends. Validated partial least square (PLS) calibration models were used to quantify each component from the NIR spectra of the blends. Additionally, effects of premixing by sieving and high shear mixing and use of an internal prism fixed within the bin on the mixing performance of each component were studied. The statistical results obtained for PLS calibration models and their validation showed the sensitivity of NIR for accurate quantification of blend components. The blend prepared with high shear premixing and with prism achieved uniformity more rapidly than that with high shear premixing but without prism during blending in a bin blender. Premixing using sieving proved to be inadequate for uniform mixing of the blend components as none of the components except MgSt achieved uniform distribution after the preset blending time when blended in the bin blender. This study demonstrated that by high speed sampling and rapid spectral acquisition, distribution of individual blend components can be assessed with high accuracy during blending. Furthermore, high shear premixing facilitated rapid distribution and uniformity achievement of blend components. This technique may be used to monitor the relative distribution of individual blend components in real time and thus, to assess the performance of a bin blender for mixing of cohesive multi-component powder blends during development and production." @default.
• W2053805265 created "2016-06-24" @default.
• W2053805265 creator A5010598928 @default.
• W2053805265 creator A5020074724 @default.
• W2053805265 creator A5065237300 @default.
• W2053805265 date "2010-02-15" @default.
• W2053805265 modified "2023-09-25" @default.
• W2053805265 title "In-line quantification of drug and excipients in cohesive powder blends by near infrared spectroscopy" @default.
• W2053805265 cites W110534203 @default.
• W2053805265 cites W187604686 @default.
• W2053805265 cites W1966261854 @default.
• W2053805265 cites W2003395526 @default.
• W2053805265 cites W2010242857 @default.
• W2053805265 cites W2010742141 @default.
• W2053805265 cites W2015776762 @default.
• W2053805265 cites W2021760717 @default.
• W2053805265 cites W2022110298 @default.
• W2053805265 cites W2023892467 @default.
• W2053805265 cites W2024813813 @default.
• W2053805265 cites W2043322796 @default.
• W2053805265 cites W2045616002 @default.
• W2053805265 cites W2047796313 @default.
• W2053805265 cites W2049244822 @default.
• W2053805265 cites W2057515372 @default.
• W2053805265 cites W2061062968 @default.
• W2053805265 cites W2067251637 @default.
• W2053805265 cites W2068882246 @default.
• W2053805265 cites W2071614864 @default.
• W2053805265 cites W2075173555 @default.
• W2053805265 cites W2075455679 @default.
• W2053805265 cites W2077443527 @default.
• W2053805265 cites W2088004614 @default.
• W2053805265 cites W2089540857 @default.
• W2053805265 cites W2092218393 @default.
• W2053805265 cites W2109219887 @default.
• W2053805265 cites W2112091560 @default.
• W2053805265 cites W2144700031 @default.
• W2053805265 cites W2148654703 @default.
• W2053805265 cites W2149909440 @default.
• W2053805265 cites W2153296949 @default.
• W2053805265 cites W2537138366 @default.
• W2053805265 cites W281838288 @default.
• W2053805265 cites W2530086839 @default.
• W2053805265 cites W2993460087 @default.
• W2053805265 doi "https://doi.org/10.1016/j.ijpharm.2009.11.011" @default.
• W2053805265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19922776" @default.
• W2053805265 hasPublicationYear "2010" @default.
• W2053805265 type Work @default.
• W2053805265 sameAs 2053805265 @default.
• W2053805265 citedByCount "68" @default.
• W2053805265 countsByYear W20538052652012 @default.
• W2053805265 countsByYear W20538052652013 @default.
• W2053805265 countsByYear W20538052652014 @default.
• W2053805265 countsByYear W20538052652015 @default.
• W2053805265 countsByYear W20538052652016 @default.
• W2053805265 countsByYear W20538052652017 @default.
• W2053805265 countsByYear W20538052652018 @default.
• W2053805265 countsByYear W20538052652019 @default.
• W2053805265 countsByYear W20538052652020 @default.
• W2053805265 countsByYear W20538052652021 @default.
• W2053805265 countsByYear W20538052652022 @default.
• W2053805265 countsByYear W20538052652023 @default.
• W2053805265 crossrefType "journal-article" @default.
• W2053805265 hasAuthorship W2053805265A5010598928 @default.
• W2053805265 hasAuthorship W2053805265A5020074724 @default.
• W2053805265 hasAuthorship W2053805265A5065237300 @default.
• W2053805265 hasConcept C105795698 @default.
• W2053805265 hasConcept C113196181 @default.
• W2053805265 hasConcept C11413529 @default.
• W2053805265 hasConcept C120665830 @default.
• W2053805265 hasConcept C121332964 @default.
• W2053805265 hasConcept C127413603 @default.
• W2053805265 hasConcept C138777275 @default.
• W2053805265 hasConcept C156273044 @default.
• W2053805265 hasConcept C159985019 @default.
• W2053805265 hasConcept C165838908 @default.
• W2053805265 hasConcept C185592680 @default.
• W2053805265 hasConcept C192562407 @default.
• W2053805265 hasConcept C2777239854 @default.
• W2053805265 hasConcept C2778572730 @default.
• W2053805265 hasConcept C2779251873 @default.
• W2053805265 hasConcept C2779351475 @default.
• W2053805265 hasConcept C33923547 @default.
• W2053805265 hasConcept C42360764 @default.
• W2053805265 hasConcept C43571822 @default.
• W2053805265 hasConcept C43617362 @default.
• W2053805265 hasConcept C62520636 @default.
• W2053805265 hasConcept C77281830 @default.
• W2053805265 hasConceptScore W2053805265C105795698 @default.
• W2053805265 hasConceptScore W2053805265C113196181 @default.
• W2053805265 hasConceptScore W2053805265C11413529 @default.
• W2053805265 hasConceptScore W2053805265C120665830 @default.
• W2053805265 hasConceptScore W2053805265C121332964 @default.
• W2053805265 hasConceptScore W2053805265C127413603 @default.
• W2053805265 hasConceptScore W2053805265C138777275 @default.
• W2053805265 hasConceptScore W2053805265C156273044 @default.
• W2053805265 hasConceptScore W2053805265C159985019 @default.
• W2053805265 hasConceptScore W2053805265C165838908 @default.

• next