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- W2053812241 abstract "The kinetochore is the macromolecular protein complex that directs chromosome segregation in eukaryotes. It has been widely assumed that the core kinetochore consists of proteins that are common to all eukaryotes. However, no conventional kinetochore components have been identified in any kinetoplastid genome, thus challenging this assumption of universality. Here, we report the identification of 19 kinetochore proteins (KKT1-19) in Trypanosoma brucei. The majority is conserved among kinetoplastids, but none of them has detectable homology to conventional kinetochore proteins. These proteins instead have a variety of features not found in conventional kinetochore proteins. We propose that kinetoplastids build kinetochores using a distinct set of proteins. These findings provide important insights into the longstanding problem of the position of the root of the eukaryotic tree of life." @default.
- W2053812241 created "2016-06-24" @default.
- W2053812241 creator A5027929813 @default.
- W2053812241 creator A5031038205 @default.
- W2053812241 date "2014-03-01" @default.
- W2053812241 modified "2023-10-14" @default.
- W2053812241 title "Discovery of Unconventional Kinetochores in Kinetoplastids" @default.
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- W2053812241 doi "https://doi.org/10.1016/j.cell.2014.01.049" @default.
- W2053812241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3978658" @default.
- W2053812241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24582333" @default.
- W2053812241 hasPublicationYear "2014" @default.
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