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• W2053817261 abstract "T cell activation by specific antigen results in a rapid and long-lasting downregulation of triggered T cell receptors (TCRs). In this work, we investigated the fate of downregulated TCR– CD3-ζ complexes. T cells stimulated by peptide-pulsed antigen-presenting cells (APCs) undergo an antigen dose-dependent decrease of the total cellular content of TCR-β, CD3-ε, and ζ chains, as detected by FACS® analysis on fixed and permeabilized T–APC conjugates and by Western blot analysis on cell lysates. The time course of CD3-ζ chain consumption overlaps with that of TCR downregulation, indicating that internalized TCR–CD3 complexes are promptly degraded. Inhibitors of lysosomal function (bafilomycin A1, folimycin) markedly reduced ζ chain degradation, leading to the accumulation of ζ chain in large Lamp1+ vesicles. These results indicate that in T cell–APC conjugates, triggered TCRs are rapidly removed from the cell surface and are degraded in the lysosomal compartment." @default.
• W2053817261 created "2016-06-24" @default.
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• W2053817261 date "1997-05-19" @default.
• W2053817261 modified "2023-09-30" @default.
• W2053817261 title "Degradation of T Cell Receptor (TCR)–CD3-ζ Complexes after Antigenic Stimulation" @default.
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• W2053817261 doi "https://doi.org/10.1084/jem.185.10.1859" @default.
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