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- W2053818072 abstract "We report a study on the regulation by 2-chloro adenosine (2CA) of a glutamate (Glu) transporter in myogenic C2C12 cells. Long-term 2CA exposition significantly increased the V(max) of the Glu transporter. Moreover, 2CA-treated cells responded to Glu challenge by a rapid and transient increase in their intracellular calcium level. The above reported effects were totally abolished by treating C2C12 cells with the Na(+)-dependent Glu transporter inhibitors DL-threo-b-hydroxyaspartic acid and L-trans-pyrrolidine-2,4-dicarboxylic acid. We propose that the possible link between the Glu uptake increase and the Glu induction of calcium rise could be the depolarizing currents carried by Na(+) coupled with transporter activity." @default.
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- W2053818072 date "2002-08-15" @default.
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- W2053818072 title "Glutamate-induced calcium increase in myotubes depends on up-regulation of a sodium-dependent transporter" @default.
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- W2053818072 doi "https://doi.org/10.1016/s0014-5793(02)03200-3" @default.
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