FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053818391> ?p ?o ?g. }

• W2053818391 endingPage "198" @default.
• W2053818391 startingPage "189" @default.
• W2053818391 abstract "To determine the respective role of the IL-12 and IL-4 pathways in the pathogenesis of systemic lupus erythematosus, we bred the Stat4 and Stat6 null alleles onto the lupus-prone mouse B6.TC, which is a congenic derivative of NZM2410. This model is characterized by abnormal splenocyte expansion, distribution and architecture, T cell activation, peripheral B cell development, production of anti-nuclear antibodies, and proliferative glomerulonephritis. STAT4 deficiency normalized the expression of each of these disease markers toward or to C57BL/6 levels. In contrast, STAT6 deficiency impacted splenocyte expansion and architecture, T cell activation, and anti-nuclear autoantibody production, but without any significant effect on B cell development or renal pathology. These results show that the IL-12/STAT4 pathway is involved in multiple disease-associated phenotypes in the B6.TC mouse. In contrast, the IL-4/STAT6 pathway regulates only a subset of disease markers that did not affect renal pathology." @default.
• W2053818391 created "2016-06-24" @default.
• W2053818391 creator A5002019326 @default.
• W2053818391 creator A5013548060 @default.
• W2053818391 creator A5026532447 @default.
• W2053818391 creator A5055739238 @default.
• W2053818391 date "2006-08-01" @default.
• W2053818391 modified "2023-10-18" @default.
• W2053818391 title "STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus" @default.
• W2053818391 cites W1494550040 @default.
• W2053818391 cites W1551211408 @default.
• W2053818391 cites W1562508597 @default.
• W2053818391 cites W1567448654 @default.
• W2053818391 cites W1598692059 @default.
• W2053818391 cites W1606632249 @default.
• W2053818391 cites W1650168614 @default.
• W2053818391 cites W1863259474 @default.
• W2053818391 cites W1929136736 @default.
• W2053818391 cites W1932956512 @default.
• W2053818391 cites W1959856035 @default.
• W2053818391 cites W1964532403 @default.
• W2053818391 cites W1980857453 @default.
• W2053818391 cites W1982548356 @default.
• W2053818391 cites W2002287074 @default.
• W2053818391 cites W2012628280 @default.
• W2053818391 cites W2015479125 @default.
• W2053818391 cites W2018412076 @default.
• W2053818391 cites W2030534966 @default.
• W2053818391 cites W2030657137 @default.
• W2053818391 cites W2031279257 @default.
• W2053818391 cites W2036315247 @default.
• W2053818391 cites W2044979143 @default.
• W2053818391 cites W2047151651 @default.
• W2053818391 cites W2054327643 @default.
• W2053818391 cites W2056158918 @default.
• W2053818391 cites W2080487841 @default.
• W2053818391 cites W2081877633 @default.
• W2053818391 cites W2100763709 @default.
• W2053818391 cites W2111046769 @default.
• W2053818391 cites W2111940985 @default.
• W2053818391 cites W2131808186 @default.
• W2053818391 cites W2138483765 @default.
• W2053818391 cites W2144628518 @default.
• W2053818391 cites W2149965740 @default.
• W2053818391 cites W2155440953 @default.
• W2053818391 cites W2159494386 @default.
• W2053818391 cites W4313310005 @default.
• W2053818391 doi "https://doi.org/10.1016/j.clim.2006.03.009" @default.
• W2053818391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16713741" @default.
• W2053818391 hasPublicationYear "2006" @default.
• W2053818391 type Work @default.
• W2053818391 sameAs 2053818391 @default.
• W2053818391 citedByCount "49" @default.
• W2053818391 countsByYear W20538183912012 @default.
• W2053818391 countsByYear W20538183912013 @default.
• W2053818391 countsByYear W20538183912014 @default.
• W2053818391 countsByYear W20538183912015 @default.
• W2053818391 countsByYear W20538183912017 @default.
• W2053818391 countsByYear W20538183912018 @default.
• W2053818391 countsByYear W20538183912019 @default.
• W2053818391 countsByYear W20538183912021 @default.
• W2053818391 countsByYear W20538183912022 @default.
• W2053818391 countsByYear W20538183912023 @default.
• W2053818391 crossrefType "journal-article" @default.
• W2053818391 hasAuthorship W2053818391A5002019326 @default.
• W2053818391 hasAuthorship W2053818391A5013548060 @default.
• W2053818391 hasAuthorship W2053818391A5026532447 @default.
• W2053818391 hasAuthorship W2053818391A5055739238 @default.
• W2053818391 hasConcept C104317684 @default.
• W2053818391 hasConcept C134018914 @default.
• W2053818391 hasConcept C142724271 @default.
• W2053818391 hasConcept C159654299 @default.
• W2053818391 hasConcept C163764329 @default.
• W2053818391 hasConcept C203014093 @default.
• W2053818391 hasConcept C2776912625 @default.
• W2053818391 hasConcept C2778277574 @default.
• W2053818391 hasConcept C2778923194 @default.
• W2053818391 hasConcept C2779134260 @default.
• W2053818391 hasConcept C2780091579 @default.
• W2053818391 hasConcept C2780368995 @default.
• W2053818391 hasConcept C2780942790 @default.
• W2053818391 hasConcept C55493867 @default.
• W2053818391 hasConcept C62478195 @default.
• W2053818391 hasConcept C65439459 @default.
• W2053818391 hasConcept C71924100 @default.
• W2053818391 hasConcept C84951073 @default.
• W2053818391 hasConcept C86803240 @default.
• W2053818391 hasConcept C95444343 @default.
• W2053818391 hasConceptScore W2053818391C104317684 @default.
• W2053818391 hasConceptScore W2053818391C134018914 @default.
• W2053818391 hasConceptScore W2053818391C142724271 @default.
• W2053818391 hasConceptScore W2053818391C159654299 @default.
• W2053818391 hasConceptScore W2053818391C163764329 @default.
• W2053818391 hasConceptScore W2053818391C203014093 @default.
• W2053818391 hasConceptScore W2053818391C2776912625 @default.
• W2053818391 hasConceptScore W2053818391C2778277574 @default.
• W2053818391 hasConceptScore W2053818391C2778923194 @default.
• W2053818391 hasConceptScore W2053818391C2779134260 @default.

• next