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- W2053820264 endingPage "1058" @default.
- W2053820264 startingPage "1051" @default.
- W2053820264 abstract "There is considerable public, regulatory, and scientific concern regarding human exposure to endocrine-disrupting chemicals, which include compounds that directly modulate steroid hormone receptor pathways (estrogens, antiestrogens, androgens, antiandrogens) and aryl hydrocarbon receptor (AhR) agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Based on quantitative structure-activity relationships for both AhR and estrogen receptor (ER) agonists, the relative potency (RP) of individual compounds relative to a standard (e.g. TCDD and 17-beta-estradiol) have been determined for several receptor-mediated responses. Therefore, the TCDD or estrogenic equivalent (TEQ or EQ, respectively) of a mixture is defined as TEQ = sigma[T(i)]xRP(i)or EQ=sigma[E(i)]xRP(i), where T(i) and E(i) are concentrations of individual AhR or ER agonists in any mixture. This approach for risk assessment of endocrine-disrupting mixtures assumes that for each endocrine response pathway, the effects of individual compounds are essentially additive. This paper will critically examine the utility of the TEQ/EQ approach for risk assessment, the validity of the assumptions used for this approach, and the problems associated with comparing low dose exposures to xeno and natural (dietary) endocrine disruptors." @default.
- W2053820264 created "2016-06-24" @default.
- W2053820264 creator A5036575223 @default.
- W2053820264 date "1998-08-01" @default.
- W2053820264 modified "2023-09-30" @default.
- W2053820264 title "Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach." @default.
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- W2053820264 doi "https://doi.org/10.1289/ehp.98106s41051" @default.
- W2053820264 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1533329" @default.
- W2053820264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9703492" @default.
- W2053820264 hasPublicationYear "1998" @default.
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