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- W2053823009 endingPage "186" @default.
- W2053823009 startingPage "171" @default.
- W2053823009 abstract "Combination antiretroviral therapy (cART) has significantly reduced morbidity and mortality of HIV-infected patients, yet their life expectancy remains reduced compared with the general population. Most HIV-infected patients receiving cART have some persistent immune dysfunction characterized by chronic immune activation and premature aging of the immune system. Here we review biomarkers of T-cell activation (CD69, -25 and -38, HLA-DR, and soluble CD26 and -30); generalized immune activation (C-reactive protein, IL-6 and D-dimer); microbial translocation (lipopolysaccharide, 16S rDNA, lipopolysaccharide-binding protein and soluble CD14); and immune dysfunction of specific cellular subsets (T cells, natural killer cells and monocytes) in HIV-infected patients on cART and their relationship to adverse clinical outcomes including impaired CD4 T-cell recovery, as well as non-AIDS clinical events, such as cardiovascular disease." @default.
- W2053823009 created "2016-06-24" @default.
- W2053823009 creator A5004996828 @default.
- W2053823009 creator A5010048599 @default.
- W2053823009 creator A5015502141 @default.
- W2053823009 creator A5044812818 @default.
- W2053823009 creator A5062645957 @default.
- W2053823009 creator A5068114811 @default.
- W2053823009 date "2011-04-01" @default.
- W2053823009 modified "2023-09-26" @default.
- W2053823009 title "Biomarkers of immune dysfunction following combination antiretroviral therapy for HIV infection" @default.
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