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- W2053832243 abstract "The gene nm23-H1 (Steeg, JNCI, 80, 1988) has been considered as a tumour suppresor gene implicated in metastatic spread. In some murine and human tumours, as breast cancer, its expression is linked to a low metastatic potential and a better prognostic. We have studied the nm23-H1 protein expression and the clinical agresivity of 62 cases of colorectal cancer that had been treated with radical surgery. Expression of nm23-H1 was determined by inmunohistochemical methods, using the monoclonal antibody NCL-nm23-2. Of the 62 cases studied, 25 (40%) expressed the protein (nm23 +) and 37 (60%) did not (nm23 -). We analized the correlation between the presence or the absence of nm23 and some known clinical and hystological prognostic factors and the relapse probability, the disease free survival (DFS), and the overall survival (OS), No statistical differences were observed between the two groups in relation to lymph nodes afectation, hystological grade and CEA serum level. With a follow-up between 6 and 10 years, there were no differences in relapse appearance. DFS and OS were significantly better for nm23 - patients. 31% of the nm23 + patients and 70% of nm23 - patients were free of disease at 5 years with 26% and 52% at 10 years (p" @default.
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- W2053832243 date "1996-01-01" @default.
- W2053832243 modified "2023-09-27" @default.
- W2053832243 title "133 O - Prognostic significance of the nm23-H1 protein expression in colorectal cancer" @default.
- W2053832243 doi "https://doi.org/10.1016/0959-8049(96)84889-1" @default.
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