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- W2053840215 abstract "Ehrlich ascites tumor ceils in vitro synthesize ribonucleosides, which appear mainly in the incubation medium, by the transfer of ribose from a donor ribonucleoside to an acceptor base. In the present study, it was found that the rates of synthesis of inosine and uridine in this system were markedly enhanced in the presence of arsenate or iodoacetate. The exchange of isotope between extracellular inosine and hypoxanthine-8-C 14 was similarly enhanced by arsenate, but the more rapid exchange between uridine and uracil-2-C 14 was unaffected. Arsenate did not cause changes in the rates of uridine breakdown that would account for the enhanced rate of nucleoside synthesis and did not promote the release of nucleoside-synthesizing enzymes from the tumor cells into the incubation medium. Because lactate formation during the uridine-supported synthesis of inosine was markedly inhibited by arsenate and iodoacetate, the increase in ribonucleoside synthesis appears to be indirect and to be related to inhibition of ribose phosphate catabolism." @default.
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- W2053840215 date "1965-10-01" @default.
- W2053840215 modified "2023-09-23" @default.
- W2053840215 title "ENHANCEMENT OF RIBONUGLEOSIDE SYNTHESIS IN EHRLICH ASCITES TUMOR CELLS BY ARSENATE AND IODOACETATE" @default.
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- W2053840215 doi "https://doi.org/10.1139/o65-187" @default.
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