Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053847338> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2053847338 endingPage "71" @default.
- W2053847338 startingPage "67" @default.
- W2053847338 abstract "SAR approaches to the study of genotoxic phenomena are finding increased applications. However, the data being modeled are frequently not considered optimal due to the small size of the dataset and an uneven distribution of genotoxicants and non-genotoxicants in the dataset. The effects of such imbalances on the performance of one SAR approach were investigated with respect to the modeling of the induction of unscheduled DNA synthesis in rat hepotocytes and of sister chromatid exchanges and chromosomal aberrations in cultural CHO cells. The analyses indicate that if genotoxicants exceed non-genotoxicants, the performance of the SAR model can be improved if the dataset is supplemented with physiological chemicals which are assumed to be non-genotoxicants. On the other hand, if non-genotoxicants exceed genotoxicants, it was found that the predictive performance of the resulting SAR model is not improved by removal of genotoxicants from the dataset to achieve a ratio of genotoxicants/genotoxicants of unity. Overall, the present analyses did not result in the development of SAR models of greatly increased predictivity. Conceivably, for the particular datasets and SAR paradigm the limit of predictivity has been reached. The possibility of investigating the use of a battery of SAR paradigms should be considered." @default.
- W2053847338 created "2016-06-24" @default.
- W2053847338 creator A5073709590 @default.
- W2053847338 date "2004-04-01" @default.
- W2053847338 modified "2023-09-28" @default.
- W2053847338 title "SAR modeling of genotoxic phenomena: the consequence on predictive performance of deviation from a unity ratio of genotoxicants/non-genotoxicants" @default.
- W2053847338 cites W1555194031 @default.
- W2053847338 cites W1977686729 @default.
- W2053847338 cites W1990583680 @default.
- W2053847338 cites W1995587214 @default.
- W2053847338 cites W1997149778 @default.
- W2053847338 cites W2002784026 @default.
- W2053847338 cites W2008764714 @default.
- W2053847338 cites W2018636731 @default.
- W2053847338 cites W2022085453 @default.
- W2053847338 cites W2033603259 @default.
- W2053847338 cites W2035805239 @default.
- W2053847338 cites W2045615383 @default.
- W2053847338 cites W2056368315 @default.
- W2053847338 cites W2058969453 @default.
- W2053847338 cites W2062188490 @default.
- W2053847338 cites W2064144593 @default.
- W2053847338 cites W2066702956 @default.
- W2053847338 cites W2075652548 @default.
- W2053847338 cites W2079436612 @default.
- W2053847338 cites W2080530497 @default.
- W2053847338 cites W2086190989 @default.
- W2053847338 cites W2087390252 @default.
- W2053847338 cites W2090319274 @default.
- W2053847338 cites W2116483187 @default.
- W2053847338 cites W2155863033 @default.
- W2053847338 cites W3215540893 @default.
- W2053847338 doi "https://doi.org/10.1016/j.mrgentox.2003.12.010" @default.
- W2053847338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15066575" @default.
- W2053847338 hasPublicationYear "2004" @default.
- W2053847338 type Work @default.
- W2053847338 sameAs 2053847338 @default.
- W2053847338 citedByCount "9" @default.
- W2053847338 countsByYear W20538473382012 @default.
- W2053847338 countsByYear W20538473382018 @default.
- W2053847338 countsByYear W20538473382019 @default.
- W2053847338 countsByYear W20538473382022 @default.
- W2053847338 crossrefType "journal-article" @default.
- W2053847338 hasAuthorship W2053847338A5073709590 @default.
- W2053847338 hasConcept C70721500 @default.
- W2053847338 hasConcept C86803240 @default.
- W2053847338 hasConceptScore W2053847338C70721500 @default.
- W2053847338 hasConceptScore W2053847338C86803240 @default.
- W2053847338 hasIssue "1-2" @default.
- W2053847338 hasLocation W20538473381 @default.
- W2053847338 hasLocation W20538473382 @default.
- W2053847338 hasOpenAccess W2053847338 @default.
- W2053847338 hasPrimaryLocation W20538473381 @default.
- W2053847338 hasRelatedWork W1641042124 @default.
- W2053847338 hasRelatedWork W1990804418 @default.
- W2053847338 hasRelatedWork W1993764875 @default.
- W2053847338 hasRelatedWork W2013243191 @default.
- W2053847338 hasRelatedWork W2046158694 @default.
- W2053847338 hasRelatedWork W2051339581 @default.
- W2053847338 hasRelatedWork W2082860237 @default.
- W2053847338 hasRelatedWork W2117258802 @default.
- W2053847338 hasRelatedWork W2130076355 @default.
- W2053847338 hasRelatedWork W2151865869 @default.
- W2053847338 hasVolume "559" @default.
- W2053847338 isParatext "false" @default.
- W2053847338 isRetracted "false" @default.
- W2053847338 magId "2053847338" @default.
- W2053847338 workType "article" @default.