Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053852539> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2053852539 endingPage "A352" @default.
- W2053852539 startingPage "A352" @default.
- W2053852539 abstract "Estimate the effect size, by means of odds ratios, of explanatory variables on the reimbursement decision by the Scottish Medicines Consortium (SMC). SMC submissions between 2008-01-01 until 2011-02-01 were reviewed. From these, 23 a priori defined predictor variables were extracted. Among these were “BI“ i.e. high and low net budget impact defined as above £500,000, “certainty-of-ICER“ defined as an ICER (base-case or sensitivity analysis) above £30,000, “comparator” defined as active or placebo/uncontrolled trial and “Childhood disease” i.e. the application is for a childhood disease or not, with childhood defined as below or above 18 years of age. The impact of these variables was estimated by means of odds ratios in univariate and multivariate logistic regression analyses. Two hundred forty-nine drug applications were reviewed; 151 (61%) received a positive recommendation and 98 (39%) were rejected by SMC. Based on the univariate analyses the following variables were included in the final multivariate model: “BI“, “certainty-of-ICER “, “comparator” and “Childhood disease”. The other 19 variables such as chronic use, negative risk profile, type of endpoint and societal impact were excluded during the backward selection process for the multivariate model. A positive reimbursement was 47.3:1 more likely for “Childhood disease” versus “no Childhood disease”, 25:1 for certain versus uncertain ICER, 3.33:1 for active versus placebo/uncontrolled trial and 2.38:1 for low versus high BI. The corresponding output (OR [95%CI]) from the regression was (47.3[7.1-961.9]) for “Childhood disease”, (0.04 [0.01-0.11]) for “certainty-of-ICER “, (0.30 [0.11-0.75]) for “comparator” and (0.42 [0.16-1.10]) for “BI“. The R2 statistic for the multivariate model was 0.41 and in-sample prediction was 82%. Most critical predictors for reimbursement were uncertain ICER and Childhood disease. Future research should add granularity by also including reimbursement restrictions as outcome. External validity should be tested by out of sample predictions for new drugs." @default.
- W2053852539 created "2016-06-24" @default.
- W2053852539 creator A5019737970 @default.
- W2053852539 creator A5039926945 @default.
- W2053852539 creator A5051500813 @default.
- W2053852539 creator A5057673793 @default.
- W2053852539 creator A5067547282 @default.
- W2053852539 creator A5082321298 @default.
- W2053852539 date "2011-11-01" @default.
- W2053852539 modified "2023-09-26" @default.
- W2053852539 title "PHP104 Identifying Factors Influencing Drug Reimbursement in Scotland" @default.
- W2053852539 doi "https://doi.org/10.1016/j.jval.2011.08.655" @default.
- W2053852539 hasPublicationYear "2011" @default.
- W2053852539 type Work @default.
- W2053852539 sameAs 2053852539 @default.
- W2053852539 citedByCount "0" @default.
- W2053852539 crossrefType "journal-article" @default.
- W2053852539 hasAuthorship W2053852539A5019737970 @default.
- W2053852539 hasAuthorship W2053852539A5039926945 @default.
- W2053852539 hasAuthorship W2053852539A5051500813 @default.
- W2053852539 hasAuthorship W2053852539A5057673793 @default.
- W2053852539 hasAuthorship W2053852539A5067547282 @default.
- W2053852539 hasAuthorship W2053852539A5082321298 @default.
- W2053852539 hasBestOaLocation W20538525391 @default.
- W2053852539 hasConcept C105795698 @default.
- W2053852539 hasConcept C126322002 @default.
- W2053852539 hasConcept C142724271 @default.
- W2053852539 hasConcept C143095724 @default.
- W2053852539 hasConcept C144024400 @default.
- W2053852539 hasConcept C144301174 @default.
- W2053852539 hasConcept C149923435 @default.
- W2053852539 hasConcept C151956035 @default.
- W2053852539 hasConcept C156957248 @default.
- W2053852539 hasConcept C160735492 @default.
- W2053852539 hasConcept C161584116 @default.
- W2053852539 hasConcept C162324750 @default.
- W2053852539 hasConcept C199163554 @default.
- W2053852539 hasConcept C204787440 @default.
- W2053852539 hasConcept C27081682 @default.
- W2053852539 hasConcept C2779134260 @default.
- W2053852539 hasConcept C2779703844 @default.
- W2053852539 hasConcept C33923547 @default.
- W2053852539 hasConcept C38180746 @default.
- W2053852539 hasConcept C50522688 @default.
- W2053852539 hasConcept C71924100 @default.
- W2053852539 hasConceptScore W2053852539C105795698 @default.
- W2053852539 hasConceptScore W2053852539C126322002 @default.
- W2053852539 hasConceptScore W2053852539C142724271 @default.
- W2053852539 hasConceptScore W2053852539C143095724 @default.
- W2053852539 hasConceptScore W2053852539C144024400 @default.
- W2053852539 hasConceptScore W2053852539C144301174 @default.
- W2053852539 hasConceptScore W2053852539C149923435 @default.
- W2053852539 hasConceptScore W2053852539C151956035 @default.
- W2053852539 hasConceptScore W2053852539C156957248 @default.
- W2053852539 hasConceptScore W2053852539C160735492 @default.
- W2053852539 hasConceptScore W2053852539C161584116 @default.
- W2053852539 hasConceptScore W2053852539C162324750 @default.
- W2053852539 hasConceptScore W2053852539C199163554 @default.
- W2053852539 hasConceptScore W2053852539C204787440 @default.
- W2053852539 hasConceptScore W2053852539C27081682 @default.
- W2053852539 hasConceptScore W2053852539C2779134260 @default.
- W2053852539 hasConceptScore W2053852539C2779703844 @default.
- W2053852539 hasConceptScore W2053852539C33923547 @default.
- W2053852539 hasConceptScore W2053852539C38180746 @default.
- W2053852539 hasConceptScore W2053852539C50522688 @default.
- W2053852539 hasConceptScore W2053852539C71924100 @default.
- W2053852539 hasIssue "7" @default.
- W2053852539 hasLocation W20538525391 @default.
- W2053852539 hasOpenAccess W2053852539 @default.
- W2053852539 hasPrimaryLocation W20538525391 @default.
- W2053852539 hasRelatedWork W1828158523 @default.
- W2053852539 hasRelatedWork W1969442050 @default.
- W2053852539 hasRelatedWork W1999135230 @default.
- W2053852539 hasRelatedWork W2082153206 @default.
- W2053852539 hasRelatedWork W2160813944 @default.
- W2053852539 hasRelatedWork W2233351104 @default.
- W2053852539 hasRelatedWork W2600861132 @default.
- W2053852539 hasRelatedWork W3146652434 @default.
- W2053852539 hasRelatedWork W4226042254 @default.
- W2053852539 hasRelatedWork W3123176164 @default.
- W2053852539 hasVolume "14" @default.
- W2053852539 isParatext "false" @default.
- W2053852539 isRetracted "false" @default.
- W2053852539 magId "2053852539" @default.
- W2053852539 workType "article" @default.