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• W2053854196 abstract "Turning up the BACE: Incorporation of an isonicotinic core into oxadiazolyl tertiary carbinamine-based inhibitors of BACE-1 has led to the identification of an exquisitely potent inhibitor, which displays good Papp and low susceptibility to the P-gp efflux pump. Upon twice daily oral administration to monkeys, co-dosed with ritonavir, this inhibitor was shown to penetrate the CNS and lower Aβ42 levels in the CSF by >40 % over the 3 day course of the experiment." @default.
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• W2053854196 date "2009-01-05" @default.
• W2053854196 modified "2023-10-14" @default.
• W2053854196 title "Evolution of Tertiary Carbinamine BACE‐1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing" @default.
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• W2053854196 doi "https://doi.org/10.1002/cmdc.200800308" @default.
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