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- W2053859498 endingPage "324" @default.
- W2053859498 startingPage "312" @default.
- W2053859498 abstract "Uncoupling protein (UCP) 3 (UCP3) is a mitochondrial anion carrier protein with highly selective expression in skeletal muscle. Despite a great deal of interest, to date neither its molecular mechanism nor its biochemical and physiological functions are well understood. Based on its high degree of homology to the original UCP (UCP1), early studies examined a role for UCP3 in thermogenesis. However, evidence for such a function is lacking. Recent studies have focused on two distinct, but not mutually exclusive, hypotheses: 1) UCP3 mitigates reactive oxygen species (ROS) production, and 2) UCP3 is somehow involved in fatty acid (FA) translocation. While supportive evidence exists for both hypotheses, the interpretation of the corresponding evidence has created some controversy. Mechanistic studies examining mitigated ROS production have been largely conducted in vitro, and the physiological significance of the findings is questioned. Conversely, while physiological evidence exists for FA translocation hypotheses, the evidence is largely correlative, leaving causal relationships unexplored. This review critically assesses evidence for the hypotheses and attempts to link the outcomes from mechanistic studies to physiological implications. Important directions for future studies, using current and novel approaches, are discussed." @default.
- W2053859498 created "2016-06-24" @default.
- W2053859498 creator A5014760843 @default.
- W2053859498 creator A5044829219 @default.
- W2053859498 creator A5066038243 @default.
- W2053859498 date "2007-01-03" @default.
- W2053859498 modified "2023-10-16" @default.
- W2053859498 title "Uncoupling protein‐3: clues in an ongoing mitochondrial mystery" @default.
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