Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053860567> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2053860567 endingPage "96" @default.
- W2053860567 startingPage "75" @default.
- W2053860567 abstract "The aim of this study was to investigate the reproducibility of carcinogenic potencies estimated by multistage model (and its linearized form) fitting to dose-response relationships referring to different rodent species and strains, different sexes, target organs and severity of prognosis. Methylene chloride represented a useful example since there were 11 single dose-response relationships available for the same administration route (inhalation) and for the above-mentioned variables. The multistage mathematical model and the 'linearized multistage' model (EPA's conservative procedure), which are the mainly adopted models for regulatory purposes, were used for the dose-response fitting of single trends and other different cumulative trends. The reproducibility of response frequencies at equal exposure doses was also analyzed. The mathematical function best describing each trend showed the constant presence of a linear component (for low doses) and, in the majority of cases, a quadratic second order component. Carcinogenic potencies were fairly consistent for the various parameters. A good interspecies reproducibility of carcinogenic potencies was observed. A high intraspecies reproducibility was also observed, even though obtained from different sexes, as well as varying degrees of severity of prognosis and, in the case of rats, different strains. The fluctuation of the estimated carcinogenic potencies was lower in mice than in rats." @default.
- W2053860567 created "2016-06-24" @default.
- W2053860567 creator A5008369420 @default.
- W2053860567 creator A5069053607 @default.
- W2053860567 creator A5084784161 @default.
- W2053860567 date "1990-12-01" @default.
- W2053860567 modified "2023-09-27" @default.
- W2053860567 title "Reproducibility of carcinogenic potencies estimated in different rodent species. methylene chloride: A useful example" @default.
- W2053860567 cites W1978003916 @default.
- W2053860567 cites W1980597479 @default.
- W2053860567 cites W2057475309 @default.
- W2053860567 cites W2072472721 @default.
- W2053860567 cites W2315613245 @default.
- W2053860567 cites W2413278938 @default.
- W2053860567 cites W2415748597 @default.
- W2053860567 cites W3085323863 @default.
- W2053860567 cites W3143448731 @default.
- W2053860567 cites W3203698495 @default.
- W2053860567 doi "https://doi.org/10.1016/0300-483x(90)90080-z" @default.
- W2053860567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2274971" @default.
- W2053860567 hasPublicationYear "1990" @default.
- W2053860567 type Work @default.
- W2053860567 sameAs 2053860567 @default.
- W2053860567 citedByCount "1" @default.
- W2053860567 crossrefType "journal-article" @default.
- W2053860567 hasAuthorship W2053860567A5008369420 @default.
- W2053860567 hasAuthorship W2053860567A5069053607 @default.
- W2053860567 hasAuthorship W2053860567A5084784161 @default.
- W2053860567 hasConcept C105795698 @default.
- W2053860567 hasConcept C114246631 @default.
- W2053860567 hasConcept C178790620 @default.
- W2053860567 hasConcept C185592680 @default.
- W2053860567 hasConcept C186060115 @default.
- W2053860567 hasConcept C18903297 @default.
- W2053860567 hasConcept C2776954882 @default.
- W2053860567 hasConcept C2777454769 @default.
- W2053860567 hasConcept C2778695967 @default.
- W2053860567 hasConcept C2778914748 @default.
- W2053860567 hasConcept C33070731 @default.
- W2053860567 hasConcept C33923547 @default.
- W2053860567 hasConcept C42219234 @default.
- W2053860567 hasConcept C55493867 @default.
- W2053860567 hasConcept C71924100 @default.
- W2053860567 hasConcept C86803240 @default.
- W2053860567 hasConcept C98274493 @default.
- W2053860567 hasConcept C9893847 @default.
- W2053860567 hasConceptScore W2053860567C105795698 @default.
- W2053860567 hasConceptScore W2053860567C114246631 @default.
- W2053860567 hasConceptScore W2053860567C178790620 @default.
- W2053860567 hasConceptScore W2053860567C185592680 @default.
- W2053860567 hasConceptScore W2053860567C186060115 @default.
- W2053860567 hasConceptScore W2053860567C18903297 @default.
- W2053860567 hasConceptScore W2053860567C2776954882 @default.
- W2053860567 hasConceptScore W2053860567C2777454769 @default.
- W2053860567 hasConceptScore W2053860567C2778695967 @default.
- W2053860567 hasConceptScore W2053860567C2778914748 @default.
- W2053860567 hasConceptScore W2053860567C33070731 @default.
- W2053860567 hasConceptScore W2053860567C33923547 @default.
- W2053860567 hasConceptScore W2053860567C42219234 @default.
- W2053860567 hasConceptScore W2053860567C55493867 @default.
- W2053860567 hasConceptScore W2053860567C71924100 @default.
- W2053860567 hasConceptScore W2053860567C86803240 @default.
- W2053860567 hasConceptScore W2053860567C98274493 @default.
- W2053860567 hasConceptScore W2053860567C9893847 @default.
- W2053860567 hasIssue "1-2" @default.
- W2053860567 hasLocation W20538605671 @default.
- W2053860567 hasLocation W20538605672 @default.
- W2053860567 hasOpenAccess W2053860567 @default.
- W2053860567 hasPrimaryLocation W20538605671 @default.
- W2053860567 hasRelatedWork W2029790424 @default.
- W2053860567 hasRelatedWork W2053860567 @default.
- W2053860567 hasRelatedWork W2067251397 @default.
- W2053860567 hasRelatedWork W2081068877 @default.
- W2053860567 hasRelatedWork W2406553224 @default.
- W2053860567 hasRelatedWork W4233893482 @default.
- W2053860567 hasRelatedWork W4248133114 @default.
- W2053860567 hasRelatedWork W4253842034 @default.
- W2053860567 hasRelatedWork W4300804371 @default.
- W2053860567 hasRelatedWork W4301478073 @default.
- W2053860567 hasVolume "65" @default.
- W2053860567 isParatext "false" @default.
- W2053860567 isRetracted "false" @default.
- W2053860567 magId "2053860567" @default.
- W2053860567 workType "article" @default.