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• W2053862916 abstract "Discovery of 5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamides as a new class of malonyl-coenzyme A decarboxylase (MCD) inhibitors is described. tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate (5, CBM-301940) exhibited excellent potency and in vivo PK/ADME properties. It is the most powerful stimulant of glucose oxidation reported to date in isolated working rat hearts. Compound 5 improved the cardiac efficiency and function in a rat heart global ischemia/reperfusion model, suggesting MCD inhibitors may be useful for the treatment of ischemic heart diseases." @default.
• W2053862916 created "2016-06-24" @default.
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• W2053862916 date "2006-06-17" @default.
• W2053862916 modified "2023-10-10" @default.
• W2053862916 title "Discovery of Potent and Orally Available Malonyl-CoA Decarboxylase Inhibitors as Cardioprotective Agents" @default.
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• W2053862916 doi "https://doi.org/10.1021/jm0605029" @default.
• W2053862916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16821767" @default.
• W2053862916 hasPublicationYear "2006" @default.
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