FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053863124> ?p ?o ?g. }

• W2053863124 endingPage "3812" @default.
• W2053863124 startingPage "3802" @default.
• W2053863124 abstract "Cancer progression involves multiple complex and interdependent steps, including progressive proliferation, angiogenesis and metastases. The complexity of these processes requires a comprehensive elucidation of the integrated signaling networks for better understanding. EAPII interacts with multiple cancer-related proteins, but its biological significance in cancer development remains unknown. In this report we identified the elevated level of EAPII protein in non-small-cell lung carcinoma (NSCLC) patients and NSCLC cell lines in culture. The oncogenic role of EAPII in lung cancer development was demonstrated using NSCLC cells with genetic manipulations that influence EAPII expression: EAPII overexpression increases proliferation of NSCLC cells with an accelerated transition of cell cycle and facilitates xenograft tumor growth in vivo; EAPII knockdown results in apoptosis of NSCLC cells and reduces xenograft tumor formation. To further explore the mechanism of EAPII's oncogenic role in lung cancer development and to elucidate the potential signaling pathway(s) that EAPII may impact, we employed antibody array to investigate the alternation of the major signaling pathways in NSCLC cells with altered EAPII level. We found that EAPII overexpression significantly activated Raf1 and ERK1/2, but not c-Jun N-terminal kinase and p38 pathways. Consistently, the protein and mRNA levels of MYC and cyclin D1, which are targets of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK–ERK) pathway, are significantly increased by EAPII overexpression. Taken together, we demonstrated that EAPII is an oncogenic factor and the activation of MAPK–ERK signaling pathway by EAPII may contribute to lung cancer development." @default.
• W2053863124 created "2016-06-24" @default.
• W2053863124 creator A5002275826 @default.
• W2053863124 creator A5015060656 @default.
• W2053863124 creator A5022570940 @default.
• W2053863124 creator A5029012836 @default.
• W2053863124 creator A5059710197 @default.
• W2053863124 creator A5066598654 @default.
• W2053863124 date "2011-04-11" @default.
• W2053863124 modified "2023-09-27" @default.
• W2053863124 title "Oncogenic role of EAPII in lung cancer development and its activation of the MAPK–ERK pathway" @default.
• W2053863124 cites W1611210979 @default.
• W2053863124 cites W1991974261 @default.
• W2053863124 cites W2002050764 @default.
• W2053863124 cites W2004774286 @default.
• W2053863124 cites W2011424260 @default.
• W2053863124 cites W2028163972 @default.
• W2053863124 cites W2029618334 @default.
• W2053863124 cites W2031852326 @default.
• W2053863124 cites W2037174767 @default.
• W2053863124 cites W2039157245 @default.
• W2053863124 cites W2039543422 @default.
• W2053863124 cites W2039781495 @default.
• W2053863124 cites W2056086531 @default.
• W2053863124 cites W2056120923 @default.
• W2053863124 cites W2056592932 @default.
• W2053863124 cites W2061457199 @default.
• W2053863124 cites W2067988713 @default.
• W2053863124 cites W2070766926 @default.
• W2053863124 cites W2072137406 @default.
• W2053863124 cites W2072461648 @default.
• W2053863124 cites W2075091190 @default.
• W2053863124 cites W2077907123 @default.
• W2053863124 cites W2088393598 @default.
• W2053863124 cites W2088663324 @default.
• W2053863124 cites W2112738731 @default.
• W2053863124 cites W2114570899 @default.
• W2053863124 cites W2116221424 @default.
• W2053863124 cites W2128680272 @default.
• W2053863124 cites W2130090902 @default.
• W2053863124 cites W2130756483 @default.
• W2053863124 cites W2156660543 @default.
• W2053863124 cites W2161786232 @default.
• W2053863124 cites W2165712565 @default.
• W2053863124 cites W2168280552 @default.
• W2053863124 cites W4234236664 @default.
• W2053863124 cites W4238492599 @default.
• W2053863124 doi "https://doi.org/10.1038/onc.2011.94" @default.
• W2053863124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3220271" @default.
• W2053863124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21478903" @default.
• W2053863124 hasPublicationYear "2011" @default.
• W2053863124 type Work @default.
• W2053863124 sameAs 2053863124 @default.
• W2053863124 citedByCount "31" @default.
• W2053863124 countsByYear W20538631242012 @default.
• W2053863124 countsByYear W20538631242013 @default.
• W2053863124 countsByYear W20538631242014 @default.
• W2053863124 countsByYear W20538631242015 @default.
• W2053863124 countsByYear W20538631242016 @default.
• W2053863124 countsByYear W20538631242017 @default.
• W2053863124 countsByYear W20538631242018 @default.
• W2053863124 countsByYear W20538631242019 @default.
• W2053863124 countsByYear W20538631242020 @default.
• W2053863124 crossrefType "journal-article" @default.
• W2053863124 hasAuthorship W2053863124A5002275826 @default.
• W2053863124 hasAuthorship W2053863124A5015060656 @default.
• W2053863124 hasAuthorship W2053863124A5022570940 @default.
• W2053863124 hasAuthorship W2053863124A5029012836 @default.
• W2053863124 hasAuthorship W2053863124A5059710197 @default.
• W2053863124 hasAuthorship W2053863124A5066598654 @default.
• W2053863124 hasBestOaLocation W20538631241 @default.
• W2053863124 hasConcept C121608353 @default.
• W2053863124 hasConcept C126322002 @default.
• W2053863124 hasConcept C184235292 @default.
• W2053863124 hasConcept C199835354 @default.
• W2053863124 hasConcept C2776256026 @default.
• W2053863124 hasConcept C2780394083 @default.
• W2053863124 hasConcept C29537977 @default.
• W2053863124 hasConcept C502942594 @default.
• W2053863124 hasConcept C54355233 @default.
• W2053863124 hasConcept C555283112 @default.
• W2053863124 hasConcept C57074206 @default.
• W2053863124 hasConcept C62112901 @default.
• W2053863124 hasConcept C62478195 @default.
• W2053863124 hasConcept C71924100 @default.
• W2053863124 hasConcept C86803240 @default.
• W2053863124 hasConcept C95444343 @default.
• W2053863124 hasConceptScore W2053863124C121608353 @default.
• W2053863124 hasConceptScore W2053863124C126322002 @default.
• W2053863124 hasConceptScore W2053863124C184235292 @default.
• W2053863124 hasConceptScore W2053863124C199835354 @default.
• W2053863124 hasConceptScore W2053863124C2776256026 @default.
• W2053863124 hasConceptScore W2053863124C2780394083 @default.
• W2053863124 hasConceptScore W2053863124C29537977 @default.
• W2053863124 hasConceptScore W2053863124C502942594 @default.
• W2053863124 hasConceptScore W2053863124C54355233 @default.
• W2053863124 hasConceptScore W2053863124C555283112 @default.
• W2053863124 hasConceptScore W2053863124C57074206 @default.

• next